ArticleThe Journal of nutrition2025
Pinto Bean Supplementation Modulates Gut Microbiota and Improves Markers of Gut Integrity in a Mouse Model of Estrogen Deficiency.
Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Resistant Starch Supplementation Modulates Gut Microbiota, Short-Chain Fatty Acids, and Markers of Gut Barrier Integrity in Estrogen-Deficient Mice.Current developments in nutrition · 2026Article
- Modulating the gut ecosystem dietary, probiotic, and novel interventions for bone health in postmenopausal women.Frontiers in immunology · 2026Review
- Gut microbiota in perimenopausal atherosclerosis: the estrogen-gut-vascular axis and personalized cardiovascular prevention.Frontiers in endocrinology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
backgroundEmerging research suggests that changes in gut microbiota play a key role in menopause-related diseases by modulating gut health.
objectivesThis study investigated the effects of pinto bean (PB) supplementation on gut integrity in an estrogen-deficient mouse model.
methodsSixty 3-mo-old female C57BL/6J mice were injected with either sesame oil (vehicle) or vinylcyclohexene diepoxide (VCD, 160 mg/kg) for 30 d to induce estrogen deficiency. Mice were then randomly assigned to 2 dietary groups (n = 15/group): control (AIN-93M) or AIN-93M + 10% (wt/wt) PB for 16 wk. Ovarian failure was confirmed by uterine weight and serum follicle-stimulating hormone (FSH). Gut health was assessed by measuring tight junction proteins, β-glucuronidase activity, short-chain fatty acids (SCFAs), and 16S microbiota composition. PB was evaluated for its estrogenic effects by molecular docking analysis of the identified polyphenols against estrogen receptor (ER)-α and ER-β. Data were analyzed by 2-way analysis of variance, with estrogen status (VCD) and diet as factors followed by post hoc tests when significant (P < 0.05) interaction effect was observed.
resultsVCD significantly (P
conclusionsPB supplementation improves gut microbial diversity and integrity in estrogen deficiency, offering potential benefits for menopause-related gut health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.