Evidence map›Paper›PMID 40680726›Full record

ArticleCell chemical biology2025

Powering the powerhouse: Mitochondrial NADPH propels oxidative metabolism.

Riley J Wedan, Sara M Nowinski

Abstract read
In one paragraph

Article in Cell chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Riley J WedanDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA; College of Human Medicine, Michigan State University, Grand Rapids, MI, USA.
Sara M NowinskiDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA. Electronic address: sara.nowinski@vai.org.

Funding

Regulation of mitochondrial fatty acid synthesis in the control of mitochondrial metabolism.R35GM151245 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI Sara Marie Nowinski · 2023 to 2026
$1.9M
Upstream Requirements for the Regulation of Mitochondrial Bioenergetics by the Mitochondrial Acyl Carrier ProteinF30GM154476 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI Riley Wedan · 2024 to 2026
$146k
NIGMS NIH HHS F30 GM154476NIGMS NIH HHS R35 GM151245
6 · The paper itself

Abstract

Mitochondrial NADPH is abundant, but the reason why was uncertain. In a study published in Nature Cell Biology, Kim et al.

Indexed as

Fatty AcidsMitochondriaNADPAnimalsHumansOxidation-ReductionFatty AcidsNADP

Identifiers

PMID40680726
PMCPMC12507123

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.