ArticleThe Journal of surgical research2025
Inflammatory Cytokines Outperform Endotheliopathy Markers as Early Predictors of Mortality in Trauma.
Article in The Journal of surgical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Early Immune Alterations in Adult Patients with Trauma According to Injury Severity: Cell-Death Patterns and Inflammatory Mediator Profiles.Journal of clinical medicine · 2026Article
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8 authors.
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Abstract
introductionTrauma induces cellular injury, coagulopathy, and a dysregulated physiologic response that results from endotheliopathy and the inflammatory response. This study aimed to compare early serum markers of endotheliopathy versus inflammatory cytokines to predict 30-day mortality in critically ill trauma patients.
methodsSerum samples were collected from 232 trauma patients on admission to the intensive care unit. Twelve endothelial markers were analyzed, including angiopoietin 1, E-selectin, P-selectin, syndecan-1, thrombomodulin, and vascular endothelial growth factors. Inflammatory cytokines analyzed included eotaxin, interleukin (IL) 1 receptor antagonist, IL-6, IL-8, IL-10, interferon-gamma inducible protein-10, and monocyte chemoattractant protein-. The primary outcome was 30-day mortality with subgroup analyses based on transfusion status at 6 hours.
resultsSubjects were 67% White, 67% male, with a median age of 58 years (34, 75). Injuries were 88% blunt with a median injury severity score of 21 (14, 30) and a 7.3% mortality rate. Mortality did not differ by transfusion status. No endothelial marker was associated with mortality, even for transfusion subgroups. By contrast, six inflammatory cytokines were associated with 30-day mortality (P < 0.05). Inflammatory markers remained associated with mortality in the no transfusion cohort for eotaxin (P = 0.04), IL-6 (P = 0.005), and IL-8 (P = 0.02), and the submassive transfusion cohort for IL-6 (P = 0.045), IL-8 (P = 0.04), and interferon-gamma inducible protein-10 (P = 0.02).
conclusionsPostinjury inflammatory markers collected at the time of intensive care unit admission offer potential 30-day mortality predictive value even in patients who do not undergo massive transfusion. In contrast, early markers of endotheliopathy may not predict mortality.
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