ArticleThe Journal of surgical research2025
Dynamics of Circulating Endothelial Injury Markers Following Kidney Transplantation.
Article in The Journal of surgical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Endothelial Glycocalyx in Kidney Transplantation: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities.International journal of molecular sciences · 2026Review
- Synergistic effects of platelet-rich fibrin and CTLA4Ig gene-transfected porcine skin on accelerating wound healing in a rat model of deep second-degree burns: a mechanistic study.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionEndotheliopathy is well studied in chronic kidney disease, brought on by the chronic stressors of proinflammatory cytokines and reactive oxygen species. However, the endothelial response to renal transplantation has not been well investigated. This study aimed to evaluate circulating biomarkers of endothelial injury acutely after renal transplantation.
methodsSerum samples were collected from 51 renal transplant patients preoperatively, immediately postoperatively, and at 24 and 72 h postoperatively. Serum was then analyzed for biomarkers of endotheliopathy, including E-selectin, P-selectin, syndecan-1, thrombomodulin, and vascular endothelial growth factors.
resultsPatients were 51% male with a median age of 58 [45, 64] years, and 65% Caucasian. Eighty percent of patients underwent deceased donor kidney transplant (DDKT), and 20% underwent living donor kidney transplant (LDKT). Twenty percent of transplants were complicated by delayed graft function (DGF). Most endothelial biomarkers were highest preoperatively, including P-selectin, matrix metalloproteinase-1, vascular endothelial growth factor (VEGF)-A, VEGF-D, VEGF-R2, and very late antigen (VLA)-4 (P < 0.05). In contrast, platelet endothelial cell adhesion molecule-1 increased, peaking at 72 h postoperatively (P < 0.001). Furthermore, DDKT recipients had higher levels of postoperative thrombomodulin compared with LDKT recipients (P = 0.03), and patients with DGF were more likely to have higher perioperative levels of VEGF-A (P < 0.05).
conclusionsMost biomarkers of endothelial injury, including adhesion proteins and mediators of endothelial cell migration and survival, decrease acutely after renal transplantation, with a rise in platelet endothelial cell adhesion molecule-1 being the exception. In subgroup analyses, thrombomodulin was elevated in DDKT compared to LDKT recipients, and perioperative VEGF-A elevation was correlated with DGF diagnosis. The etiology of these changes, whether by organ implantation alone or by associated immunosuppression, merits further investigation.
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