ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025
The association of a polygenic lifespan score with the risk of common age-related diseases and mortality.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Leveraging human-robot interaction and virtual reality for digital biomarkers in diagnostics and rehabilitation: a review from the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Pooled it
- Genetic predisposition to longer lifespan, lifestyle factors, and all-cause mortality: a 17-year prospective cohort study.GeroScience · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundAging increases the risk of major noncommunicable diseases. Research into the genetics of health-related traits could reveal genetic pathways for robustness against these diseases. We studied how a genetic predisposition for a long lifespan is associated with the risk of all-cause mortality and major age-related noncommunicable diseases.
methodsWe analyzed data from 376 753 participants (mean age = 58.5 years; standard deviation = 13.9 years; 46.3% men) to examine how a polygenic lifespan score (PLS) is associated with the risk of all-cause mortality and major noncommunicable diseases. The associations between all-cause mortality, cancers, femur fracture, dementia, Alzheimer's disease, Parkinson's disease, type 2 diabetes, obesity, cardiovascular diseases, hypertension, ischemic heart diseases, coronary heart disease, stroke, and myocardial infarction were investigated using conventional and time-dependent Cox regression.
resultsThe PLS was associated with all the above-mentioned outcomes except for Parkinson's disease. Most of the associations were time-dependent, and the hazard ratio (HR) varied over time from protective to risk-increasing. However, the current PLS predicted noncommunicable disease risks with small effect sizes (lowest HR ≈ 0.70, highest HR ≈ 1.20, Cox-Snell pseudo-R2 > 0.01).
conclusionsGenetic predisposition for a longer lifespan was associated with a smaller risk of common age-related noncommunicable diseases, suggesting greater robustness against these conditions. The lowest risks were found during periods when the incidences of diseases were greatest. The observed small effects highlight the need to better understand how accumulated environmental factors modify individual lifespans.
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