Evidence map›Paper›PMID 40680216›Full record

ArticlePhysiological reports2025

Preclinical assessment of the selective androgen receptor modulator RAD140 to increase muscle mass and bone mineral density.

Jake Puskas, Teja Guda, Sarah Niccoli, Christopher R Rathbone, Benjamin Tan-Johnson, David Puskas, Ryan Middleton, Jeffrey S Otis, Simon J Lees

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jake PuskasDepartment of Biology, Lakehead University, Thunder Bay, Ontario, Canada.ORCID 0000-0002-8453-1997
Teja GudaDepartment of Biomedical Engineering and Chemical Engineering, University of Texas at San Antonio, San Antonio, Texas, USA.ORCID 0000-0002-3218-2916
Sarah NiccoliNorthern Ontario School of Medicine University, Thunder Bay, Ontario, Canada.ORCID 0000-0001-5832-1980
Christopher R RathboneDepartment of Biomedical Engineering and Chemical Engineering, University of Texas at San Antonio, San Antonio, Texas, USA.ORCID 0000-0002-6937-4030
Benjamin Tan-JohnsonDepartment of Biomedical Engineering and Chemical Engineering, University of Texas at San Antonio, San Antonio, Texas, USA.ORCID 0009-0005-8659-5934
David PuskasNorthern Ontario School of Medicine University, Thunder Bay, Ontario, Canada.ORCID 0000-0003-4094-4244
Ryan MiddletonDepartment of Kinesiology and Health, Georgia State University, Atlanta, Georgia, USA.ORCID 0009-0009-6061-8420
Jeffrey S OtisDepartment of Kinesiology and Health, Georgia State University, Atlanta, Georgia, USA.ORCID 0000-0003-1215-9177
Simon J LeesNorthern Ontario School of Medicine University, Thunder Bay, Ontario, Canada.ORCID 0000-0001-8892-4352

Funding

Northern Ontario Academic Medicine Association (NOAMA) A-21-15Northern Ontario School of Medicine University Research and Development Grant
6 · The paper itself

Abstract

Selective androgen receptor modulators (SARMs) are important hypertrophic molecules that are potential treatments for many types of myopathy and osteopathy. This study aimed to determine if the SARM RAD140 had additive effects on muscle hypertrophy when combined with the functional overloading (FO) of the plantaris muscle. Male, Sprague-Dawley rats (n = 10 rats/group) were randomly selected into one of four treatment groups: (1) RAD140-FO, (2) RAD140-Control, (3) Vehicle-Control, or (4) Vehicle-FO. RAD140 groups received drugs through drinking water, and control groups received only Vehicle (methylcellulose). Standard rat chow and water were provided ad libitum. Muscle weights of the triceps-surae group and muscle fiber cross-sectional area (CSA) were measured. Muscle weight analysis showed a marked increase in RAD140-FO groups but was not statistically different from the Vehicle-FO group. CSA results indicated similar findings; however, RAD140-Control showed significantly elevated CSA compared to Vehicle-Control. The tibial microarchitecture was analyzed using micro computed tomography. RAD140 did not impact cortical or trabecular bone structural morphometric properties following 14 days of treatment. The data presented here show the potential of RAD140 to stimulate muscle hypertrophy in young healthy rats.

Indexed as

Bone DensityMuscle, SkeletalReceptors, AndrogenAnimalsHypertrophyMaleRatsRats, Sprague-DawleyReceptors, Androgencross‐sectional areafunctional overloadhypertrophyRAD140SARMskeletal muscle

Identifiers

PMID40680216
PMCPMC12274021

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.