Evidence map›Paper›PMID 40680131›Full record

ArticleScience advances2025

Nicotinamide boosts oocyte quantity and quality by promoting N4-acetylation modification in lupus mice.

Yun Xie, Chuanchuan Zhou, Qi Guo, Yingchun Guo, Jiayi Guo, Lina Chen, Xiaoping Liu, Yanyan Zeng, Qiqi Liang, Taibao Wu and 2 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yun XieReproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0002-0667-6250
Chuanchuan ZhouReproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0003-1535-4509
Qi GuoReproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0001-5192-5634
Yingchun GuoReproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0003-4690-3427
Jiayi GuoReproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0003-1417-7395
Lina ChenReproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0002-3367-0110
Xiaoping LiuReproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0001-5054-9817
Yanyan ZengReproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0001-9954-1082
Qiqi LiangReproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0002-2338-2588
Taibao WuReproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0002-3257-9753
Jiawen LiuReproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0009-0005-1780-3971
Xiaoyan LiangReproductive Medicine Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0002-9701-3865

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with systemic lupus erythematosus (SLE) often have decreased fertility. Gene translation is crucial to oocyte meiosis and development. However, it remains unclear how SLE affects this process. Here, we used single-cell transcriptome and translatome sequencing to uncover a notable disruption in protein translation in oocytes from SLE mice, associated with the

Indexed as

Lupus Erythematosus, SystemicNiacinamideOocytesAcetylationAnimalsCytidineDisease Models, AnimalFemaleMiceProtein BiosynthesisCytidineNiacinamide

Identifiers

PMID40680131
PMCPMC12273787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.