Evidence map›Paper›PMID 40680026›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

N

Bradley S Jones, Vikram Pareek, Daniel D Hu, Simon D Weaver, Camille Syska, Grace Galfano, Matthew M Champion, Patricia A Champion

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Frontiers in tuberculosis · 2025
    Review
4 · The record

Corrections and comments

  • Update of
    N2024
5 · Who and what money

Authors and funding

8 authors.

Bradley S JonesDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.
Vikram PareekDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.
Daniel D HuDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.
Simon D WeaverDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.ORCID 0000-0003-4354-0309
Camille SyskaDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.ORCID 0000-0001-8632-1339
Grace GalfanoDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.
Matthew M ChampionEck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556.ORCID 0000-0001-5927-5277
Patricia A ChampionDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.ORCID 0000-0002-6733-596X

Funding

Role of N-alpha acetylation in mycobacterial secretion and virulenceR01AI106872 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHAMPION, PATRICIA A · 2013 to 2024
$4.2M
HHS | National Institutes of Health (NIH) AI106872NIAID NIH HHS R01 AI106872
6 · The paper itself

Abstract

Phagosomal lysis is essential for mycobacterial infection of macrophages. Acetylation is a protein modification mediated enzymatically by N-acetyltransferases (NATs) that impacts bacterial pathogenesis and physiology. To identify NATs required for lytic activity, we leveraged

Indexed as

AcetyltransferasesAminoglycosidesDrug Resistance, BacterialIronMycobacterium marinumAnimalsBacterial ProteinsGlycolipidsLipidsMacrophagesMiceMycobacterium Infections, NontuberculousOxazolesSiderophoresVirulenceAcetyltransferasesAminoglycosidesBacterial ProteinsGlycolipidsIronLipidsmycobactinsOxazolesphthiocerol dimycocerosateSiderophoresacetylationGNATMbtKMycobacteriumPDIM

Identifiers

PMID40680026
PMCPMC12305045

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.