ArticlePLOS digital health2025
An artificial intelligence-based approach to identify volume status in patients with severe dengue using wearable PPG data.
Article in PLOS digital health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Dengue virus infection.Nature reviews. Disease primers · 2026Review
- Serial bedside echocardiography identifies children at risk of recurrent Dengue shock: a prospective cohort study.BMC emergency medicine · 2026Article
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue shock syndrome (DSS) is a serious complication of dengue infection which occurs when critical plasma leakage results in haemodynamic shock. Treatment is challenging as fluid therapy must balance the risk of hypoperfusion with volume overload. In this study, we investigate the potential utility of wearable photoplethysmography (PPG) to determine volume status in DSS. In this prospective observational study, we enrolled 250 adults and children with a clinical diagnosis of dengue admitted to the Hospital for Tropical Diseases, Ho Chi Minh City. PPG monitoring using a wearable device was applied for a 24-hour period. Clinical events were then matched to the PPG data by date and time. We predefined two clinical states for comparison: (1) the 2-hour period before a shock event was an "empty" volume state and (2) the 2-hour period between 1 and 3 hours after a fluid initiation event was a "full" volume state. PPG data were sampled from these states for analysis. Variability and waveform morphology features were extracted and analyzed using principal components analysis and random forest. Waveform images were used to develop a computer vision model. Of the 250 patients enrolled, 90 patients experienced the predefined outcomes, and had sufficient data for the analysis. Principal components analysis identified four principal components (PCs), from the 23 pulse wave features. Logistic regression using these PCs showed that the empty state is associated with PCs 1 (p = 0.016) and 4 (p = 0.036) with both PCs denoting increased sympathetic activity. Random forest showed that heart rate and the LF-HF ratio are the most important features. A computer vision model had a sensitivity of 0.81 and a specificity of 0.70 for the empty state. These results provide proof of concept that an artificial intelligence-based approach using continuous PPG monitoring can provide information on volume states in DSS.
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Registered trials
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