Evidence map›Paper›PMID 40679913›Full record

ArticleCell reports2025

Intradental mechano-nociceptors serve as sentinels that prevent tooth damage.

Elizabeth A Ronan, Akash R Gandhi, Karin H Uchima Koecklin, Yujia Hu, Shuhao Wan, Brian S C Constantinescu, Mak E Guenther, Maximilian Nagel, Ling-Yu Liu, Aditi Jha and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Elizabeth A RonanDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Akash R GandhiDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Karin H Uchima KoecklinDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Yujia HuLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Shuhao WanDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Brian S C ConstantinescuDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Mak E GuentherDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Maximilian NagelSensory Cells and Circuits Section, National Center for Complementary and Integrative Health, Bethesda, MD 20892, USA.
Ling-Yu LiuDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Aditi JhaDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Leen DakhilallaDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Kaitlyn J BlumbergDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Isaac T BerthaumeDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Tomer SternDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Kevin P PipeDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Bing YeLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Peng LiDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Joshua J EmrickDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: jjemrick@umich.edu.

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Sensory Mechanisms and Disorders - Administrative SupplementT32DC000011 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Michael Thomas Roberts · 1989 to 2026
$9.5M
Defining the Targets and Function of Direct Trigeminal Sensory Innervation to Salivary GlandsR01DE032345 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Isabelle M.A. Lombaert · 2023 to 2026
$2.5M
Dissecting neural circuits for breathing patternsR01AT011652 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LI, PENG · 2021 to 2025
$2.1M
Neural circuit control of sighingR01HL156989 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LI, PENG · 2022 to 2025
$1.5M
Determining the functions of tooth-innervating neurons in dental sensationK22DE029779 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EMRICK, JOSHUA JAMES · 2022 to 2024
$742k
NCCIH NIH HHS R01 AT011652NHLBI NIH HHS R01 HL156989NIDCD NIH HHS T32 DC000011NIDCR NIH HHS K22 DE029779NIDCR NIH HHS R01 DE032345NIDCR NIH HHS T32 DE007057
6 · The paper itself

Abstract

The trigeminal sensory neurons that innervate the tooth's vital interior-intradental neurons-are expected to drive severe pain, yet their contribution to healthy tooth sensation has not been explored. Here, we uncover a role for myelinated high-threshold mechano-nociceptors (intradental HTMRs) in tooth protection using in vivo Ca

Indexed as

MechanoreceptorsNociceptorsToothTooth InjuriesAnimalsFemaleIon ChannelsMaleMiceMice, Inbred C57BLIon ChannelsPiezo2 protein, mouseCP: Neurosciencecraniofacial biologydentininteroceptionmechanoreceptorsnociceptionpainsensorimotor reflexsomatosensationtooth pulp biologytrigeminal

Identifiers

PMID40679913
PMCPMC12442953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.