Evidence map›Paper›PMID 40679912›Full record

ArticleCell reports2025

Signaling by intracellular β

Boram Lee, Xiaomin Xing, Erik A Hammes, Zhuoer Zeng, Zoila M Estrada-Tobar, Karam Kim, Kyle E Ireton, Kwun Nok Mimi Man, Ariel A Jacobi, Ruben A Berumen and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The working lives of neuronal 5-HTRSC chemical biology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Boram LeeDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Xiaomin XingDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Erik A HammesDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Zhuoer ZengDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Zoila M Estrada-TobarDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Karam KimDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Kyle E IretonDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Kwun Nok Mimi ManDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Ariel A JacobiDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Ruben A BerumenDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Justin C WeinerDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Ao ShenDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Bing XuDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA; VA Northern California Health Care System, Mather, CA 95655, USA.
Joanne WangDepartment of Pharmaceutics, University of Washington, Seattle, WA 98195-7280, USA.
Paul J GasserDepartment of Biomedical Sciences, Marquette University, Milwaukee, WI 53201-1881, USA.
Manuel F NavedoDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Yang K XiangDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA; VA Northern California Health Care System, Mather, CA 95655, USA.
Elva DíazDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Chao-Yin ChenDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Mary C HorneDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA.
Johannes W HellDepartment of Pharmacology, University of California, Davis, Davis, CA 95616-8636, USA. Electronic address: jwhell@ucdavis.edu.

Funding

UC Davis MCB T32 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) MentorshipT32GM007377 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHEDIN, FREDERIC LOUIS · 1985 to 2023
$9.9M
The plasma membrane monoamine transporter (PMAT): expression and role in mIBG disposition in neuroblastomaR01GM066233 · NIGMS · UNIVERSITY OF WASHINGTON · PI WANG, JOANNE · 2002 to 2020
$5.1M
Role of a-actinin in Cav1.2 FunctionR01AG055357 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOHANNES W HELL · 2016 to 2026
$4.0M
SynDIG1/Prrt1 regulation of extrasynaptic GluA1-containing AMPARs during plasticityR01MH119347 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DIAZ, ELVA D, HELL, JOHANNES W · 2019 to 2024
$3.3M
Training Program in Basic NeuroscienceT32MH082174 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI W MARTIN USREY · 2007 to 2026
$3.1M
Cerebral Vascular Smooth Muscle Dysfunction in Alzheimer's DiseaseR01HL149127 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2019 to 2022
$2.7M
Phosphodiesterases govern nuclear cAMP signaling for gene expressionR01MH134119 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG Kevin XIANG · 2023 to 2026
$2.6M
cAMP signaling in vascular smooth muscle in health and diseaseR01HL161872 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2022 to 2025
$2.6M
Learning, Memory, and Plasticity (LaMP) Training ProgramT32MH112507 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Karen Zito · 2017 to 2026
$2.4M
Postsynaptic Signaling by Norepinephrine and cAMPR01NS123050 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOHANNES W HELL · 2022 to 2026
$2.3M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Mechanisms underlying secondhand smoke-induced cardiovascular dysfunctionR01ES025229 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, CHAO-YIN · 2015 to 2019
$2.1M
NHLBI NIH HHS R01 HL149127NHLBI NIH HHS R01 HL161872NIA NIH HHS R01 AG055357NIA NIH HHS RF1 AG055357NIDA NIH HHS R01 DA032895NIEHS NIH HHS R01 ES025229NIGMS NIH HHS R01 GM066233NIGMS NIH HHS R01 GM129376NIGMS NIH HHS T32 GM007377NIGMS NIH HHS T32 GM099608NIGMS NIH HHS T32 GM144303NIGMS NIH HHS T32 GM144304NIMH NIH HHS R01 MH119347NIMH NIH HHS R01 MH134119NIMH NIH HHS T32 MH082174NIMH NIH HHS T32 MH112507NINDS NIH HHS F99 NS135807NINDS NIH HHS R01 NS123050
6 · The paper itself

Abstract

Signaling by norepinephrine (NE) via adrenergic receptors (ARs) mediates attention, yet the underlying molecular mechanisms are largely unknown. AMPA receptors (AMPARs) form a complex with β

Indexed as

Neuronal PlasticityReceptors, Adrenergic, beta-2Receptors, AMPASignal TransductionAnimalsCyclic AMP-Dependent Protein KinasesHumansLong-Term PotentiationMiceNeuronsNorepinephrinePhosphorylationProtein TransportRatsCyclic AMP-Dependent Protein KinasesNorepinephrineReceptors, Adrenergic, beta-2Receptors, AMPAAMPA receptorsCP: Cell biologyCP: NeuroscienceLTPnorepinephrineorganic cation transporterplasma membrane monoamine transporterβ(2)-adrenergic receptor

Identifiers

PMID40679912
PMCPMC12579434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.