Evidence map›Paper›PMID 40679821›Full record

ArticleJournal of proteome research2025

The Identification by Shotgun Proteomics with High-Resolution Tandem Mass-Spectrometry of Histone Isoforms' Hypermethylation Phenotype as a Hallmark Characteristic of Human-IDH-Mutant High-Grade Gliomas: Epigenetic Applications for Genotoxicity-Based Biomarkers and Cancer Therapy Targets.

Kaouthar Louati, Fatma Kolsi, Manel Mellouli, Hanen Louati, Rania Zribi, Rim Kallel, Mahdi Borni, Yassine Gdoura, Leila Sellami Hakim, Amina Maalej and 10 more

Abstract read
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In one paragraph

Article in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Kaouthar LouatiFaculty of Pharmacy, Laboratory of Chemical, Galenic & Pharmacological Drug Development- LR12ES09, University of Monastir, Road Avicenne, Monastir 5000, Tunisia.ORCID 0000-0001-5085-4766
Fatma KolsiFaculty of Medicine, University of sfax, Avenue of Majida Boulila, Sfax 3029, Tunisia.
Manel MellouliFaculty of Medicine, University of sfax, Avenue of Majida Boulila, Sfax 3029, Tunisia.
Hanen LouatiCollege of administrative and financial sciences, Saudi Electronic University, Riyadh 11673, Saudi- Arabia.
Rania ZribiFaculty of Letters and Humanities, University of sfax, Airport Road, Km 4.5, Sfax 3023, Tunisia.
Rim KallelFaculty of Medicine, University of sfax, Avenue of Majida Boulila, Sfax 3029, Tunisia.
Mahdi BorniFaculty of Medicine, University of sfax, Avenue of Majida Boulila, Sfax 3029, Tunisia.
Yassine GdouraFaculty of Medicine, University of sfax, Avenue of Majida Boulila, Sfax 3029, Tunisia.
Leila Sellami HakimLaboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia.
Amina MaalejLaboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177, Sfax 3018, Tunisia.
Sirine ChouraLaboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177, Sfax 3018, Tunisia.
Mohamed ChamkhaLaboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177, Sfax 3018, Tunisia.
Sami SayadiBiotechnology Program, Center for Sustainable Development, College of Arts and Sciences, Qatar University, Doha 2713, Qatar.
Basma MnifFaculty of Medicine, University of sfax, Avenue of Majida Boulila, Sfax 3029, Tunisia.
Zouheir KhemakhemFaculty of Medicine, University of sfax, Avenue of Majida Boulila, Sfax 3029, Tunisia.
Tahya Sellami BoudawaraFaculty of Medicine, University of sfax, Avenue of Majida Boulila, Sfax 3029, Tunisia.
Mohamed Zaher BoudawaraFaculty of Medicine, University of sfax, Avenue of Majida Boulila, Sfax 3029, Tunisia.
Abderrahman BouraouiFaculty of Pharmacy, Laboratory of Chemical, Galenic & Pharmacological Drug Development- LR12ES09, University of Monastir, Road Avicenne, Monastir 5000, Tunisia.
Jamil KraiemFaculty of Pharmacy, Laboratory of Chemical, Galenic & Pharmacological Drug Development- LR12ES09, University of Monastir, Road Avicenne, Monastir 5000, Tunisia.
Fathi SaftaFaculty of Pharmacy, Laboratory of Chemical, Galenic & Pharmacological Drug Development- LR12ES09, University of Monastir, Road Avicenne, Monastir 5000, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histone post-translational modifications (PTMs) have been linked to various pathological processes, especially in cancer onset, where they are envisaged as obvious diagnostic biomarkers and pivotal predictors for pathological prognosis. Consequently, their mapping and characterization constitute a critical field of study facilitated by recent advances in the high-throughput mass spectrometry technique. The current study aimed to clarify the neurotoxicity mechanisms at the epigenetic level induced by environmental stressors by examining their potential to induce aberrant histone methylation as it is the most involved modification in carcinogenesis. Our protocol first consisted of a 3D

Indexed as

Brain NeoplasmsEpigenesis, GeneticGliomaHistonesIsocitrate DehydrogenaseProteomicsBiomarkers, TumorCell Line, TumorHumansMethylationMutationPhenotypeProtein IsoformsProtein Processing, Post-TranslationalTandem Mass SpectrometryBiomarkers, TumorHistonesIsocitrate DehydrogenaseProtein IsoformsbiomarkersepigeneticshistonesIDH mutant high-grade gliomasmass-spectrometryneurospheroidspost-translational modificationsshotgun proteomics

Identifiers

PMID40679821
PMCPMC12418497

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.