SynthesisCardiovascular intervention and therapeutics2025
Impact of aortic angulation on outcomes in transcatheter aortic valve replacement with balloon-expandable and self-expanding valves: a systematic review and meta-analysis.
Synthesis in Cardiovascular intervention and therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Sex-specific anatomical challenges in TAVR: A closer look at bicuspid aortic valve stenosis.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis and Cardiogenic Shock.Circulation reports · 2026Article
- Increased Aortic Angulation in Transcatheter Aortic Valve Implantation-Still a Challenging Anatomy?Interdisciplinary cardiovascular and thoracic surgery · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High aortic angulation (AA) can pose significant challenges during TAVR. This meta-analysis determines the impact of a horizontal aorta on TAVR outcomes with balloon-expandable (BEV) and self-expanding valves (SEVs). A comprehensive search was conducted from inception to June 2024. Thirteen observational studies assessing the impact of aortic angulation in patients undergoing TAVR replacement were included. The pooled results indicated that short-term mortality was significantly lower in patients with a non-horizontal aorta (RR = 0.76; 95% CI 0.62-0.95, P = 0.01). Subgroup analysis displayed that BEVs had a lower short-term mortality with a horizontal aorta than SEVs. The incidence of stroke was not significantly affected by aortic angulation with either valve type. However, the overall risk of permanent pacemaker implantation was lower in patients with a non-horizontal aorta for both valve types. Paravalvular regurgitation was also reduced in the non-horizontal aorta group, with no difference between aortic angulations in patients with BEVs. In contrast, SEVs favored a non-horizontal aorta in reducing paravalvular leak (RR = 0.66; 95% CI 0.46-0.94, P = 0.02). Both BEVs and SEVs show better results in patients with lower aortic root angulation. The increased incidence of conduction abnormalities and PPI rates with both valve types in patients with horizontal aorta is a concern. BEVs could be potentially used preferentially to SEVs in patients with a horizontal aorta as there was no difference between horizontal and non-horizontal aorta groups regarding short-term mortality, moderate-to-severe paravalvular leak, and need for a second valve.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.