ArticleEuropean geriatric medicine2025
Osteosarcopenia, sarcopenia, and their associations with validated recent fragility fractures in older women: applying seven definitions in the FRISBEE 2 study.
Article in European geriatric medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of osteosarcopenia in postmenopausal women: a systematic review and meta-analysis.Journal of endocrinological investigation · 2026Pooled it
- Osteosarcopenia in Cardiac Surgery: Standardization, Selection Bias, and Outcome Definition Matter.Geriatrics & gerontology international · 2026Article
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Authors and funding
11 authors.
Funding
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Abstract
purposeWe assessed the associations between osteosarcopenia, sarcopenia (according to seven definitions), and the presence of radiologically validated recent osteoporotic fractures in community-dwelling older women from the Fracture Risk Brussels Epidemiological Enquiry (FRISBEE2) study.
methodsRetrospective cohort design. The FRISBEE2 study includes 907 community-dwelling women aged 77 (75-81) years. Sarcopenia (according to six consensual definitions: EWGSOP2 "probable" and "confirmed"; IWGS; SCWD; SDOC; FNIH, and as seventh, an exploratory, potential framework for the GLIS), osteoporosis (T-score ≤ - 2.5SD), and osteosarcopenia (osteoporosis plus each of the 7 sarcopenia definitions) were assessed at baseline. We recorded and radiologically validated recent (i.e., within 2 years before baseline) central or major osteoporotic fractures (MOFs). Multivariate regression models adjusted for age, BMI, sedentary lifestyle, and comorbidities, were used to evaluate associations between osteosarcopenia and sarcopenia at baseline with the presence of recent fractures.
resultsAs expected, the prevalence of osteosarcopenia and sarcopenia varied widely depending on the definitions used. Out of the 907 included women, 47 (5.2%) had experienced a recent fracture. The crude analysis showed significant associations between osteosarcopenia, osteoporosis, and sarcopenia and the presence of recent fractures. In the multivariate analysis, only EWGSOP2-defined probable sarcopenia (i.e., low handgrip strength) was associated with recent fractures [OR = 2.14 (1.05-4.35); p = 0.035].
conclusionsOlder women with a history of recent fracture had EWGSOP2-defined probable sarcopenia (i.e., low handgrip strength). A recent central or MOF should alert on probable sarcopenia. Further prospective studies are needed to explore the role of muscle strength as a modifiable risk factor for fractures.
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