ReviewCell biochemistry and biophysics2025
The miRNA Landscape of Leukemia - Cellular Actions to Therapy through Molecular Mechanisms.
Review in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
Funding
Abstract
The Nobel Prize in Physiology and Medicine awarded to Victor Ambros and Gary Ruvkun for their work in microRNA (miRNA) emphasized the important role that miRNA plays in biology. These conserved small noncoding RNA molecules play pivotal role especially in the post transcriptional stage of gene regulation, affecting various key cellular processes by interacting with target genes complement to the conserved miRNA seed sequence. Over the years miRNA was implicated in all manners of diseases with abnormal gene regulation especially in cancer. In leukemia, miRNA dysregulation could lead to aberrant cellular processes. These include but are not limited to leukemic development, survival and drug resistance. miRNA also have important clinical implications as differential miRNA abundance could contribute towards leukemogenesis. This is especially useful in the diagnosis and prognosis of leukemia. This review aims to explore and highlight the role of miRNAs in leukemia development, progression and to discuss miRNA involvement towards leukemic resistance to therapy.
Indexed as
Identifiers
40679764What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.