Evidence map›Paper›PMID 40679761›Full record

SynthesisJournal of imaging informatics in medicine2026

Diagnostic Performance of Artificial Intelligence in Detecting and Distinguishing Pancreatic Ductal Adenocarcinoma via Computed Tomography: A Systematic Review and Meta-Analysis.

Hamid Harandi, Mahdi Gouravani, Sogol Alikarami, Mohammad Shahrabi Farahani, Mohammad Ghavam, Soheil Mohammadi, Mohammad Amin Salehi, Sean Reynolds, Fatemeh Dehghani Firouzabadi, Fahimul Huda

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Journal of imaging informatics in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hamid HarandiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mahdi GouravaniMusculoskeletal Imaging Research Center (MIRC), Tehran University of Medical Sciences, Tehran, Iran.
Sogol AlikaramiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Shahrabi FarahaniMedical Students Research Committee, Shahed University, Tehran, Iran.
Mohammad GhavamSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Soheil MohammadiMallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA.
Mohammad Amin SalehiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Sean ReynoldsDepartment of Radiology, University of Louisville School of Medicine, 530 S Jackson St. Suite C07, Louisville, KY, 40202, USA.
Fatemeh Dehghani FirouzabadiDepartment of Radiology, University of Louisville School of Medicine, 530 S Jackson St. Suite C07, Louisville, KY, 40202, USA.
Fahimul HudaDepartment of Radiology, University of Louisville School of Medicine, 530 S Jackson St. Suite C07, Louisville, KY, 40202, USA. Fahimul.huda@louisville.edu.ORCID http://orcid.org/0000-0001-7447-2711

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted a systematic review and meta-analysis in diagnostic performance of studies that tried to use artificial intelligence (AI) algorithms in detecting pancreatic ductal adenocarcinoma (PDAC) and distinguishing them from other types of pancreatic lesions. We systematically searched for studies on pancreatic lesions and AI from January 2014 to May 2024. Data were extracted and a meta-analysis was performed using contingency tables and a random-effects model to calculate pooled sensitivity and specificity. Quality assessment was done using modified TRIPOD and PROBAST tools. We included 26 studies in this systematic review, with 22 studies chosen for meta-analysis. The evaluation of AI algorithms' performance in internal validation exhibited a pooled sensitivity of 93% (95% confidence interval [CI], 90 to 95) and specificity of 95% (95% CI, 92 to 97). Additionally, externally validated AI algorithms demonstrated a combined sensitivity of 89% (95% CI, 85 to 92) and specificity of 91% (95% CI, 85 to 95). Subgroup analysis indicated that diagnostic performance differed by comparator group, image contrast, segmentation technique, and algorithm type, with contrast-enhanced imaging and specific AI models (e.g., random forest for sensitivity and CNN for specificity) demonstrating superior accuracy. Although the potential biases should be further addressed, results of this systematic review and meta-analysis showed that AI models have the potential to be incorporated in clinical settings for the detection of smaller tumors and underpinning early signs of PDAC.

Indexed as

Artificial IntelligenceCarcinoma, Pancreatic DuctalPancreatic NeoplasmsTomography, X-Ray ComputedAlgorithmsDiagnosis, DifferentialHumansSensitivity and SpecificityArtificial intelligenceComputed tomographyPancreatic ductal adenocarcinomaSystematic review and meta-analysis

Identifiers

PMID40679761
PMCPMC13103180

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.