ReviewClinical and experimental medicine2025
Tumor infiltration therapy: from FDA approval to next-generation approaches.
Review in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Combining Radiation Therapy and Tumor-Infiltrating Lymphocyte Therapy: Biological Rationale, Clinical Synergies, and Future Directions.Current oncology (Toronto, Ont.) · 2026Review
- Targeting the cancer metabolism-immunity interface: update and perspectives.Experimental hematology & oncology · 2026Review
- The evolution of cellular-based immunotherapy in the treatment of gastric cancer: an overview of clinical trials.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Plying potency assays for immunotherapy of solid tumors.Frontiers in immunology · 2026Review
- Therapeutic melanoma vaccines: Platforms, neoantigen strategies, and emerging combination immunotherapies.Therapeutic advances in vaccines and immunotherapy · 2026Review
- Tumor-infiltrating lymphocyte therapy in triple-negative breast cancer: from mechanistic exploration to clinical translation.Frontiers in immunology · 2026Review
- Terminally exhausted CD8Frontiers in immunology · 2025Review
- Tumor-infiltrating lymphocytes and tumor-associated macrophages in cancer immunoediting: a targetable therapeutic axis.Frontiers in immunology · 2025Review
- Antibody-drug conjugates versus docetaxel for previously treated advanced non-small-cell lung cancer: a systematic review and meta-analysis of randomized controlled trials.Therapeutic advances in medical oncology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor-infiltrating lymphocyte (TIL) therapy represents an emerging and promising approach in the field of cancer immunotherapy, harnessing the body's own immune cells to target and eliminate cancer cells. This review provides an in-depth analysis of TIL therapy, focusing on its mechanisms, clinical applications, challenges, and future prospects. TILs, particularly CD8 + T cells, are isolated from a patient's tumor, expanded ex vivo, and reinfused to promote anti-tumor immunity. The success of TIL therapy has been demonstrated in various cancers, particularly melanoma, where it has led to durable responses and, in some cases, complete remission. However, significant challenges remain, including the heterogeneity of TIL populations, difficulties in large-scale expansion, and immune-related adverse events. We also explore current strategies aimed at overcoming these limitations, including genetic modification of TILs, combinatory approaches with checkpoint inhibitors, and optimization of tumor infiltration protocols. With ongoing research and technological advancements, TIL therapy holds substantial promise as a cornerstone of personalized cancer treatment. This review synthesizes the current landscape of TIL therapy, providing insights into its clinical efficacy, potential for broader application, and the future of cancer immunotherapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.