ReviewMolecular and cellular biochemistry2025
Exercise and its beneficial impacts on mood disorders and neurodegeneration: a novel mechanistic perspective of the exosomes involvement.
Review in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exercise-induced hippocampal miR-212/132 expression is preserved despite psychostimulant exposure and viral infection.Brain, behavior, and immunity · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mood disorders (MDs), including depression and anxiety, are among the leading causes of global disability, yet current treatments often yield incomplete remission. Women are disproportionately affected, underscoring the need for more targeted and effective interventions. Emerging evidence suggests that small extracellular vesicles (sEVs), particularly exosomes released during aerobic exercise, may mediate its antidepressant effects by facilitating inter-organ communication and delivering neuroactive cargo, such as microRNAs, across the blood-brain barrier. These vesicles influence synaptic plasticity, neurogenesis, and inflammation, offering both mechanistic insight and biomarker potential. This review proposes that exercise-induced exosomes are key modulators of brain health and mood regulation. By synthesizing findings from human and animal studies, we explore how aerobic exercise promotes neural resilience through exosomal signaling, with attention to sex-specific hormonal influences. Understanding these pathways may inform precision-based, non-pharmacological strategies for managing mood disorders and mitigating neurodegenerative risk.
Indexed as
Identifiers
40679703What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.