Evidence map›Paper›PMID 40679701›Full record

ArticleMycopathologia2025

Clinical and Molecular Epidemiological Characteristics of 26 Bloodstream Infection Cases Caused by Candida tropicalis.

Weihong Lin, Qianyue Yang, Zhiwei Lin, Shuang Liu, Liangyan Zhang, Yueting Jiang, Jingchun Fang, Yaqin Peng, Penghao Guo

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Article in Mycopathologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Weihong Lin *Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, China.
Qianyue Yang *Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, China.
Zhiwei Lin *Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, China.
Shuang Liu *Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, China.
Liangyan ZhangDepartment of Clinical Laboratory, People's Hospital of Yuxi City & The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, China.
Yueting JiangDepartment of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou, 510120, China.
Jingchun FangDepartment of Clinical Laboratory, Nansha Division of The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 520080, China.
Yaqin PengDepartment of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 520080, China.
Penghao GuoDepartment of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 520080, China. jackgph@163.com.ORCID http://orcid.org/0009-0009-4586-4199

Funding

Guangzhou Municipal Science and Technology Bureau 202201020443
6 · The paper itself

Abstract

purposeThis study aims to investigate the clinical and molecular epidemiological characteristics of bloodstream infections caused by Candida tropicalis.

methodsThis retrospective study analyzed the clinical data of patients diagnosed with C. tropicalis bloodstream infections from January 2020 to December 2022. Antifungal susceptibility testing was performed. Multilocus sequence typing (MLST) was used to analyze strain homology, and mutation analysis of the ERG11 (azole resistance-associated) and FKS1 (echinocandin resistance-associated) genes was conducted.

resultsAmong the 26 cases of C. tropicalis bloodstream infections, hematologic malignancies were the most common underlying condition, with an overall mortality rate of 38.5%. Resistance rates to voriconazole and fluconazole were 30.8%, while the isolates exhibited high susceptibility to echinocandin drugs and amphotericin B. All fluconazole-resistant strains contained mutations in the ERG11 gene, with Y132F and S154F being the most frequent mutation sites. The mortality rate in fluconazole-resistant patients (37.5%) was similar to that of susceptible or dose-dependently susceptible patients (38.8%). A total of 20 distinct sequence types (DSTs) were identified among the 26 strains, all of which were previously known, indicating significant genetic diversity. The most abundant type was DST376.

conclusionHematologic malignancies are the most common underlying disease of C. tropicalis bloodstream infections. The isolated strains demonstrate significant genetic diversity and a high level resistance to fluconazole.

Indexed as

Candida tropicalisCandidemiaAdultAgedAged, 80 and overAntifungal AgentsDrug Resistance, FungalFemaleFungal ProteinsHematologic NeoplasmsHumansMaleMicrobial Sensitivity TestsMiddle AgedMolecular EpidemiologyMultilocus Sequence TypingAntifungal AgentsFungal ProteinsBloodstream infectionCandida tropicalisFungal drug resistance surveillanceMolecular epidemiology

Identifiers

PMID40679701
PMCPMC12274234

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