ArticlePsychopharmacology2026
Post-methamphetamine working memory decline predicts relapse vulnerability in rats and is rescued by mGlu3 receptor activation.
Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive effects of methamphetamine and amphetamine withdrawal in rodents: a systematic review.Frontiers in psychology · 2026Pooled it
- Activation of mGlu2 Receptors Rescues Persistent Post-Methamphetamine Deficit in Object-in-Place Recognition Memory.Brain sciences · 2026Article
- Individual differences in stress coping are linked to working memory performance in male and female F344 rats.Physiology & behavior · 2025Article
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Abstract
rationaleWidespread methamphetamine (meth) misuse remains a worldwide public health issue that lacks effective clinical treatment. Besides the high relapse and overdose rates, chronic meth use produces a spectrum of cognitive deficits that further complicate treatment and recovery. Activation of metabotropic glutamate receptor 3 (mGlu3) attenuates drug-seeking behavior and/or improves cognition in several animal models, though its ability to improve meth-associated behavioral deficits has not been explored.
objectivesHere, we evaluated working memory and meth-seeking following abstinence and the effects of mGlu3 activation on such behaviors.
methodsAdult male and female Sprague-Dawley rats were first trained and tested on the operant delayed match-to-sample (DMS) working memory task. Rats then underwent 7 days of short-access (1 h/day) and 14 days of long-access (6 h/day) self-administration or served as drug-naïve controls. During the first 3 weeks of abstinence, rats were re-tested on the DMS task and underwent relapse tests to evaluate meth-seeking behavior. Additionally, the effects of indirect mGlu3 activator 2-PMPA (30 mg/kg, i.p.) on both behavioral measures were assessed.
resultsMeth self-administration produced working memory impairment in both sexes. Significantly, the decline in DMS task performance predicted the magnitude of subsequent meth-seeking. 2-PMPA treatment improved DMS task performance in a cognitively impaired subgroup of rats but had no immediate effects on meth-seeking.
conclusionsThe current study shows that chronic meth self-administration in rats produces co-occurring working memory deficits and robust meth-seeking, akin to meth use disorder (MUD), and that mGlu3 manipulation holds promise in the treatment of meth-associated cognitive deficits.
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