Evidence map›Paper›PMID 40679585›Full record

ArticleAnnals of hematology2025

Clinical features and fusion gene analysis of two Torque Teno Mini virus associated acute promyelocytic leukemia cases.

Deyan Liu, Jiaqi Chen, Yu Luo, Shu Yan, Hua Nan, Xue Chen, Zhongyuan Lin, Liejun Jiang, Huihe Tang, Hongyan Ma and 9 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Deyan Liu *Department of Bone Marrow Transplantation, Hebei Yanda Lu Daopei Hospital, Langfang, 065201, China.
Jiaqi Chen *Division of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, 065201, China.
Yu Luo *Department of Clinical Laboratory, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530000, China.
Shu YanDepartment of Bone Marrow Transplantation, Hebei Yanda Lu Daopei Hospital, Langfang, 065201, China.
Hua NanDepartment of Bone Marrow Transplantation, Hebei Yanda Lu Daopei Hospital, Langfang, 065201, China.
Xue ChenDivision of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, 065201, China.
Zhongyuan LinDepartment of Clinical Laboratory, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530000, China.
Liejun JiangDepartment of Clinical Laboratory, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530000, China.
Huihe TangDepartment of Pediatrics, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530000, China.
Hongyan MaDepartment of Pediatrics, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530000, China.
Yumeng NiuDepartment of Hematology, Beijing Lu Daopei Hospital, Beijing, 100176, China.
Jiancheng FangDivision of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, 065201, China.
Panxiang CaoDivision of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, 065201, China.
Lili YuanDivision of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, 065201, China.
Xiaoli MaDivision of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, 065201, China.
Xiaosu ZhouPrecision Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, 100176, China.
Fanyong LvDepartment of Hematology, Beijing Lu Daopei Hospital, Beijing, 100176, China.
Yan DaiDepartment of Pediatrics, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530000, China. 3677458@qq.com.
Hongxing LiuDivision of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, 065201, China. starliu@pku.edu.cn.

Funding

Langfang Science and Technology Research and Development Program 2023013167
6 · The paper itself

Abstract

Torque Teno Mini Virus (TTMV), a member of the Anelloviridae family, is a commensal component of the human virome. Since the initial identification of the TTMV::RARA fusion gene as a novel driver of acute promyelocytic leukemia (APL), 15 cases have been reported in retrospective studies. With advancements in diagnostic methods and increased awareness, the number of newly diagnosed cases has risen, and the clinical and molecular characteristics of TTMV::RARA-APL are becoming clearer. We systematically identified the clinical characteristics, fusion gene analysis, and treatment protocols of two pediatric APL patients harboring the TTMV::RARA fusion on this basis. While the detection of TTMV::RARA contributes to defining pathogenic fusion gene and MRD monitoring indicators in non-PML::RARA-APL cases, the precise pathogenic mechanisms of this ubiquitous symbiotic virus warrant further investigation.

Indexed as

DNA Virus InfectionsLeukemia, Promyelocytic, AcuteOncogene Proteins, FusionTorque teno virusChildHumansMaleRetinoic Acid Receptor alphaOncogene Proteins, FusionRARA protein, humanRetinoic Acid Receptor alphaAcute promyelocytic leukemiaFusion geneTorque Teno Mini virus

Identifiers

PMID40679585
PMCPMC12432083

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.