ArticleMolecular biology reports2025
Thymus serpyllum extract exerts anticancer activities against colorectal cancer by modulating metastasis, cell cycle arrest, and apoptosis.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Synergic anticancer effects of morin hydrate and sorafenib delivered via polymeric iron oxide nanoparticles for the treatment of triple-negative breast cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Cardiotoxin from Naja atra Activates the NLRP3/Caspase-1/GSDMD Pyroptosis Pathway to Induce Skin Tissue Injury.PLoS neglected tropical diseases · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundColorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second leading cause of cancer-related mortality worldwide. Although previous studies have suggested that Thymus serpyllum may improve gastrointestinal function and exhibit anticancer properties, the precise molecular mechanisms underlying its potential effects on CRC remain poorly understood. This study aimed to investigate the anticancer efficacy of T. serpyllum extract (TSe) by assessing its effects on CRC cell proliferation, migration, invasion, and apoptosis. METHODS AND
resultsThe influence of TSe on HT-29 cells was determined using the MTT assay, colony formation assay, wound healing assay, Boyden chamber assay, cell cycle analysis, TUNEL assay, and western blotting. The effects and mechanisms of action of TSe on CRC progression were further validated using a subcutaneous tumor model. This study demonstrated that TSe significantly inhibited the proliferation, migration, and invasion of CRC cells in vitro. Mechanistically, TSe induced cell cycle arrest at the G
conclusionsThese findings suggest that TSe exerts potent antitumor effects by arresting the cell cycle and promoting apoptosis, highlighting its potential as a novel therapeutic agent against CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.