Evidence map›Paper›PMID 40679557›Full record

ArticleJournal of computer-aided molecular design2025

Design, synthesis, evaluation and molecular modeling of quinazoline derivatives bearing amino acids as small-molecule PD-L1 inhibitors.

Han Liu, Roufen Chen, Dandan Yuan, Yidan Xing, Xueyan Ding, Xingye Wu, Yali Gao, Junjie Ma

Abstract read
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In one paragraph

Article in Journal of computer-aided molecular design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Han Liu *School of Medicine, Huaqiao University, Quanzhou, 362000, China.
Roufen Chen *School of Medicine, Huaqiao University, Quanzhou, 362000, China.
Dandan YuanSchool of Medicine, Huaqiao University, Quanzhou, 362000, China.
Yidan XingSchool of Medicine, Huaqiao University, Quanzhou, 362000, China.
Xueyan DingSchool of Medicine, Huaqiao University, Quanzhou, 362000, China.
Xingye WuSchool of Medicine, Huaqiao University, Quanzhou, 362000, China.
Yali GaoPharmacy Department, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China. heygaoyali@126.com.
Junjie MaSchool of Medicine, Huaqiao University, Quanzhou, 362000, China. majunjie3612@hqu.edu.cn.

Funding

Fujian Provincial Health Technology Project 2020QNA060Fujian Provincial Key Laboratory of Innovative Drug Target Research FJ-YW-2024KF06Quanzhou High-level Talents Innovation and Entrepreneurship Project 2024QZC005YR
6 · The paper itself

Abstract

Herein, we reported a series of quinazoline derivatives bearing amino acids by introducing a rigid pyrimidine structure between the 2 and 3-positions of the biphenyl and establishing an ionic interaction with Lys124 of PD-L1. Evaluation of the PD-1/PD-L1 inhibitory activity identified compound 7, which exhibited the most potent inhibitory activity with an IC

Indexed as

Amino AcidsB7-H1 AntigenDrug DesignQuinazolinesBinding SitesHumansMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingStructure-Activity RelationshipAmino AcidsB7-H1 AntigenCD274 protein, humanQuinazolines

Identifiers

PMID40679557

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.