Evidence map›Paper›PMID 40679526›Full record

ArticleBulletin of experimental biology and medicine2025

Impairment of P2 Receptor-Mediated Modulation of Skeletal Muscle Contractions in Transgenic Mice with Modeled Amyotrophic Lateral Sclerosis.

A E Khairullin, D V Efimova, A Y Teplov, A N Khabibrakhmanov, K K Nagiev, S N Grishin, A U Ziganshin, M A Mukhamedyarov

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A E KhairullinKazan State Medical University, Kazan, Russia.
D V EfimovaKazan State Medical University, Kazan, Russia.
A Y TeplovKazan State Medical University, Kazan, Russia.
A N KhabibrakhmanovKazan State Medical University, Kazan, Russia.
K K NagievKazan State Medical University, Kazan, Russia.
S N GrishinKazan State Medical University, Kazan, Russia.
A U ZiganshinKazan State Medical University, Kazan, Russia.
M A MukhamedyarovKazan State Medical University, Kazan, Russia. marat.muhamedyarov@kazangmu.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the effects of ATP on skeletal muscle contractility in FUS-transgenic mice with amyotrophic lateral sclerosis (ALS) model. Mechanomyography showed that ATP application did not increase the amplitude of electrically induced contractions of the diaphragm muscle, m. extensor digitorum longus, and soleus muscle in FUS-transgenic mice unlike wild-type mice. Application of a non-selective P2 receptor antagonist suramine and application of ATP against the background of suramine did not change the amplitude of contractions of the studied skeletal muscles in FUS-transgenic mice. Thus, FUS model of ALS is based on the impairment of purinergic regulation of skeletal muscle contractile activity, which can play a role in the pathogenesis of ALS.

Indexed as

Amyotrophic Lateral SclerosisMuscle ContractionMuscle, SkeletalReceptors, Purinergic P2Adenosine TriphosphateAnimalsDiaphragmDisease Models, AnimalMaleMiceMice, TransgenicRNA-Binding Protein FUSAdenosine TriphosphateReceptors, Purinergic P2RNA-Binding Protein FUSamyotrophic lateral sclerosisATPneuromuscular synapseP2 receptorsskeletal muscles

Identifiers

PMID40679526

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.