ArticleBulletin of experimental biology and medicine2025
Effect of Ethylmethylhydroxypyridine Succinate on the Expression of PGC-1α, GR, SUCNR1, and SDHA Genes in the Cerebral Cortex of Old Rats during a Course of Dexamethasone Administration.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We assessed the transcriptional activity of the genes PGC-1α, GR, SUCNR1, and SDHA in the cerebral cortex of old (age 18 months) male rats receiving course administration of dexamethasone alone and in combination with ethylmethylhydroxypyridine succinate. According to real-time PCR data, the course intraperitoneal administration of the glucocorticoid receptor (GRα) agonist dexamethasone (1 mg/kg, daily for 10 days) reduced the expression of the PGC-1α, GR, SUCNR1, and SDHA genes in rat cerebral cortex. Intraperitoneal administration of ethylmethylhydroxypyridine succinate (100 mg/kg, daily for 10 days) after each dexamethasone injection normalized the expression of PGC-1α and SUCNR1 genes and significantly activated the expression of GR and SDHA. Thus, succinate/SUCNR1-mediated activation of the PGC-1α, GR, SUCNR1, and SDHA genes was detected for the first time, in the cerebral cortex of old rats during chronic stimulation of GRα with supraphysiological doses of dexamethasone.
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