Evidence map›Paper›PMID 40679514›Full record

ArticleBulletin of experimental biology and medicine2025

Thymus of Female Wistar Rats after Photodynamic Therapy of Experimental Breast Cancer in Comparison with Combination of Photodynamic Therapy and Surgical Treatment of Breast Cancer.

O V Kazakov, A V Kabakov, A F Poveshchenko, V N Cherkas, N R Bodrova

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

O V KazakovResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. kazakoff_oleg@mail.ru.
A V KabakovResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
A F PoveshchenkoResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
V N CherkasResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
N R BodrovaResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A histological study of structural changes in the thymus of female Wistar rats with chemically induced breast cancer (BC) after photodynamic therapy (PDT) and a combination of PDT and surgical treatment was conducted. After PDT, the thymus showed restoration of the cortical and medullary substance areas, as well as glandular tissue, to the values of the intact control in comparison with the pathological control (BC without treatment). PDT influences both positive and negative selection processes and the activity of T-lymphocyte differentiation processes (the number of epithelial cells and macrophages increases, the number of cells with pyknotic nuclei in the cortical and medullary substance decreases). In the cortico-medullary zone of the thymus, the number of small and medium lymphocytes increases, which may indicate an increase in lymphocyte migration from the thymus. After PDT and subsequent resection of a BC, structural changes in the thymus may indicate a decrease in its lymphopoietic function, activity of both positive and negative T-cell selection processes, as well as a decrease in the activity of T-lymphocyte differentiation processes and their migration from the thymus.

Indexed as

Mammary Neoplasms, ExperimentalPhotochemotherapyThymus GlandAnimalsCell DifferentiationCombined Modality TherapyFemalePhotosensitizing AgentsRatsRats, WistarT-LymphocytesPhotosensitizing Agentsbreast cancerphotodynamic therapysurgical treatmenttherapeutic measuresthymus

Identifiers

PMID40679514

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.