SynthesisNutrition reviews2026
The Impact of Inorganic Nitrate on Endothelial Function: A Systematic Review of Randomized Controlled Trials and Meta-analysis.
Synthesis in Nutrition reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations.International journal of molecular sciences · 2026Review
- Beetroot Juice Enhances Nitrate Metabolism and Endothelial Function but Not Cardiovascular or Strength Performance in Bodybuilders with a History of Anabolic-Androgenic Steroid Abuse: A Crossover Trial.Antioxidants (Basel, Switzerland) · 2026Article
- The compartmentalization model of nitrate homeostasis: Role of the salivary glands, skeletal muscle, and liver.EXCLI journal · 2026Review
- Plant-derived bioactives in depression-related and antidepressant-associated sexual dysfunction: a narrative review.Frontiers in nutrition · 2026Review
- Effect of Dietary Sodium Nitrite Supplementation on Spontaneous Intracerebral Hemorrhage in Stroke-Prone Spontaneously Hypertensive Rats.Preventive nutrition and food science · 2025Article
- Can Beetroot (Nutrients · 2025Review
- Source-specific nitrate intake and incident dementia in the Danish Diet, Cancer and Health Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
contextInorganic nitrate is an exogenous source of nitric oxide, an established regulator of vascular homeostasis via the nitrate-nitrite-nitric oxide pathway. Here, we evaluate the impact of inorganic nitrate on endothelial function, a risk factor for cardiovascular disease.
objectiveA systematic review of the existing literature and meta-analysis was performed. Trials testing inorganic nitrate compared with a control were selected and the change in forearm endothelial function (as assessed by flow-mediated dilatation [FMD]) were included. DATA SOURCES: The following databases were searched: Medline, Web of Science, and Scopus. DATA EXTRACTION AND ANALYSIS: Standardized mean differences in %FMD were pooled using a random-effects model and 13 studies were included in the analysis. Quality assessment was performed using the Cochrane risk-of-bias score.
resultsInorganic nitrate was associated with improved Δ%FMD compared with the control; the standardized mean difference was 1.48% (95% CI: 0.70%-2.27%; P < 0.01); high heterogeneity (I2 = 98.2%) was observed. The significant effect observed remained irrespective of dose (±600 mg nitrate), duration (acute or chronic consumption), health status (± health conditions), and type of nitrate (dietary or nondietary). Notably, acute studies had a greater FMD response than chronic studies (1.93% [95% CI: 0.71%-3.15%] vs 0.90% [95% CI: 0.48%-1.31%]). More than half of the studies reviewed showed low risk of bias; the rest of the studies were classified as "some concern" due to lack of information about randomization process and lack of prespecified analysis plans.
conclusionOur results show that, from a modest number of included trials, inorganic nitrate consumption improves FMD response by more than 1%, a clinically relevant magnitude for the prevention of cardiovascular disease. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42020191832.
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