ArticleJournal of burn care & research : official publication of the American Burn Association2025
The Metabolic Impact of Biodegradable Temporizing Matrix in Burn Patients: A Retrospective Analysis of Resting Energy Expenditure and Inflammation.
Article in Journal of burn care & research : official publication of the American Burn Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Gastrointestinal dysfunction after brain injury: Mechanisms and the role of the brain-gut axis.World journal of gastroenterology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Severe burn injuries induce a hypermetabolic state, significantly increasing resting energy expenditure (REE) and systemic inflammation, which can impact wound healing and patient recovery. Biodegradable temporizing matrix (BTM), a synthetic polyurethane dermal substitute, has been increasingly used for large TBSA burns, yet its metabolic effects remain unclear. This retrospective cohort study analyzed burn patients from 2013 to 2022 who underwent metabolic cart measurements following excision and wound coverage with autograft, allograft, or BTM. Mixed-effects linear regression modeling was performed to assess the impact of wound coverage type on REE and C-reactive protein (CRP) levels over time. Among 226 patients, those receiving BTM had significantly higher REE (+403.5 kcal, P < .05) compared to allograft when considering all-time points. However, when restricting analysis to 2-8 weeks post-excision, REE differences were not significant, while CRP levels were significantly lower in the BTM (-3.07 mg/dL, P = .0388) and autograft (-3.32 mg/dL, P = .0107) groups relative to allograft. These findings suggest that BTM use is associated with increased metabolic activity but a reduced inflammatory response over time. The observed differences in metabolic and inflammatory profiles provide insight into the biologic impact of BTM and support further investigation into its role in optimizing burn wound management and recovery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.