Evidence map›Paper›PMID 40679368›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Intestinal Epithelial-Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78-mediated Endoplasmic Reticulum Stress.

Chenchen Qian, Chenghong Hu, Yong Xu, Wentao Xu, Zhe Wang, Wan Gan, Weiyang Tang, Lijiang Huang, Aleksandr V Samorodov, Yi Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chenchen QianSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.
Chenghong HuSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.
Yong XuSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.
Wentao XuSchool of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.
Zhe WangSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.
Wan GanSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.
Weiyang TangSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.
Lijiang HuangJoint Research Center on Medicine, the Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang, 315700, China.
Aleksandr V SamorodovDepartment of Pharmacology, Bashkir State Medical University, Ufa, 450005, Russia.
Yi WangSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.ORCID 0009-0005-9347-4946

Funding

Innovation Team of Hangzhou City TD2024002Interdisciplinary Research Project of Hangzhou Normal University 2024JCXK06Key Research Project of Wenzhou City ZY2021021National Natural Science Foundation of China 82361138563National Natural Science Foundation of China 82370244Russian Science Foundation grant 24-45-00071
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a chronic condition in which endoplasmic reticulum (ER) stress and subsequent apoptosis of intestinal epithelial cells play significant roles. E3 ubiquitin ligases and deubiquitinases are crucial in IBD pathophysiology by modulating protein ubiquitination. This study investigated the regulatory role of a deubiquitinase ubiquitin-specific peptidase 13 (USP13) in a DSS-induced colitis mouse model and explored the underlying mechanism. Intestinal epithelial-specific Usp13 knockout (USP13

Indexed as

ColitisEndoplasmic Reticulum StressIntestinal MucosaUbiquitin-Specific ProteasesAnimalsApoptosisDisease Models, AnimalEndoplasmic Reticulum Chaperone BiPHumansMaleMiceMice, Inbred C57BLMice, KnockoutUbiquitinationEndoplasmic Reticulum Chaperone BiPHSPA5 protein, humanHspa5 protein, mouseUbiquitin-Specific ProteasesUSP13 protein, humanDeubiquitinaseER stressGRP78inflammatory bowel diseaseUSP13

Identifiers

PMID40679368
PMCPMC12520541

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.