Evidence map›Paper›PMID 40679358›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation.

Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Zhengyan WangDepartment of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.
Zihan LiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Lei WangSchool of Artificial Intelligence and Automation, The MOE Engineering Research Center of Autonomous Intelligent Unmanned Systems, the Key Laboratory of Image Processing, Huazhong University of Science and Technology, Wuhan, 430074, China.
Haitao ZhangSchool of Artificial Intelligence and Automation, The MOE Engineering Research Center of Autonomous Intelligent Unmanned Systems, the Key Laboratory of Image Processing, Huazhong University of Science and Technology, Wuhan, 430074, China.
Xiaoshan YangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Lili BaoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Geng DouState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Lili RenState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Yajing FuDepartment of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.
Lan LiDepartment of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.
Shengkai GongState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Yang ZhouState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Feng DingState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Lu YuDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
Haotian LuoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Yao LiuDepartment of Paediatric Dentistry, School of Stomatology, China Medical University, Shenyang, 110002, China.
Fuyang ZhangDepartment of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Hui YuWuhan Children's Hospital: Wuhan Women and Children Medical Care Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430010, China.
Siying LiuState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Xueming LiuSchool of Artificial Intelligence and Automation, The MOE Engineering Research Center of Autonomous Intelligent Unmanned Systems, the Key Laboratory of Image Processing, Huazhong University of Science and Technology, Wuhan, 430074, China.
Fulan WeiDepartment of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.
Shiyu LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.ORCID https://orcid.org/0000-0001-7972-4527

Funding

Fundamental Research Funds for the Central UniversitiesNational Key Research and Development Program of China 2021YFA1100600National Natural Science Foundation of China 62172170National Natural Science Foundation of China 82071080National Natural Science Foundation of China 82170925National Natural Science Foundation of China 82470951National Natural Science Foundation of China 82471012National Natural Science Foundation of China T2422010Shaanxi Provincial Key Research and Development Program 2024SF-GJHX-29
6 · The paper itself

Abstract

Organisms constantly encounter unpredictable environmental perturbations, necessitating adaptation to maintain homeostasis. However, the fundamental principles by which organisms identify specific cues and transition to an adaptive state remain unclear. Here, using a mouse mechanical ventilation model and a cell stretch model, it is found that the cellular adaptation to mechanical stress can be induced by applying low amplitude stretches to cells, and demonstrate that the adaptation emerges once a defined stretch threshold is reached. This adaptive state is marked by transient cell shrinkage and reduced membrane tension. Mechanistically, guided by a mathematical model of intracellular Ca

Indexed as

Adaptation, PhysiologicalCalciumStress, MechanicalAnimalsCell SizeCholesterolMiceCalciumCholesteroladaptationcholesterolextracellular vesiclesmechanical forcepositive feedback

Identifiers

PMID40679358
PMCPMC12520526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.