ArticlePharmacology research & perspectives2025
Gastrin-Releasing Peptide Facilitates Cholinergically Mediated Contractions of the Mouse Gastric Fundus.
Article in Pharmacology research & perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gastrin-releasing peptide (GRP) and neuromedin B (NMB) are found in the stomach's myenteric plexus and muscular layers. When exogenously administered, they contract stomach muscle in several species, but their ability to modulate enteric nerve functions has rarely been studied. We investigated the effects of GRP on cholinergic-mediated contractions of the stomach, after first characterizing the contractile effects of GRP, NMB, and bombesin (BB). Circular muscle rings, cut from the mouse gastric fundus, were studied using tissue bath techniques. Contractions evoked by electrical field stimulation (EFS; 5 Hz) were examined under non-adrenergic, non-nitrergic conditions. Contractions were expressed as % of the maximum contraction induced by carbachol (100 μM). GRP (0.0001-1 μM), NMB (0.0001-3 μM), and BB (0.0001-1 μM) induced concentration-dependent tonic muscle contractions. The pD
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