ArticleTranslational vision science & technology2025
Intraoperative Spectrally Encoded Coherence Tomography and Reflectometry (iSECTR) for Ophthalmic Surgical Guidance.
Article in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Purpose: We present an optimized intraoperative spectrally encoded coherence tomography and reflectometry (iSECTR) system integrated with a Zeiss OPMI VISU 200 ophthalmic surgical microscope (Zeiss, Oberkochen, Germany). Methods: An iSECTR scan-head was designed to overcome previous barriers to clinical translation by improving system stability, optimizing optical throughput, reducing reflection artifacts, and adding motorized focus-adjust functionality. The iSECTR imaging performance was demonstrated in in vivo human eyes and during simulated ophthalmic surgical maneuvers in ex vivo porcine eyes. Results: The optimized iSECTR scan-head achieved a footprint of 19.67 × 30.2 cm (width × length) and a surgical microscope stack height increase of only 6.06 cm. Motorized focusing was able to accommodate for ±10 D of focal shift to accommodate refractive power differences across surgeons. In vivo and ex vivo iSECTR imaging was able to resolve clinically relevant retinal and corneal tissue features and tissue deformation from conventional surgical instruments during simulated ophthalmic surgical maneuvers. Conclusions: This work demonstrates the performance of our iSECTR scan-head for ophthalmic intraoperative optical coherence tomography (iOCT). Our robust modular design allows for stable performance that is suitable for clinical translation. The improved spectrally encoded reflectometry (SER) imaging performance allowed for reproducible anterior and posterior eye imaging in both in vivo and ex vivo eyes, and independent iSECTR focus-adjust further enhances clinical ergonomics. Clinical translation of iSECTR technologies will provide a research platform for automated retinal- and instrument-tracking and four-dimensional visualization of surgical dynamics. Translational Relevance: Design considerations for minimizing footprint, microscope stack height, and integration of motorized focus-adjust were emphasized to benefit surgical ergonomics and clinical translation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.