Evidence map›Paper›PMID 40679301›Full record

ArticleMicrobiology spectrum2025

Performance evaluation of the NG-TEST CARBA 5 and Genobio K.N.I.V.O. detection K-Set lateral flow assays for the detection of carbapenemases.

Chloe N Calica, Neda Domjacic, Jennifer Dacanay, Ethel C de Carvalho Lopes, Mariel S Mardoquio, Yan Chen, Ramzi Fattouh

Abstract readEvaluation Study
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chloe N CalicaBioinformatics and Computational Biology, University of Toronto, Toronto, Ontario, Canada.ORCID 0009-0006-9472-9928
Neda DomjacicDivision of Microbiology, Department of Laboratory Medicine, Unity Health Toronto, Toronto, Ontario, Canada.
Jennifer DacanayDivision of Microbiology, Department of Laboratory Medicine, Unity Health Toronto, Toronto, Ontario, Canada.
Ethel C de Carvalho LopesDivision of Microbiology, Department of Laboratory Medicine, Unity Health Toronto, Toronto, Ontario, Canada.
Mariel S MardoquioDivision of Microbiology, Department of Laboratory Medicine, Unity Health Toronto, Toronto, Ontario, Canada.
Yan Chen *Division of Microbiology, Department of Laboratory Medicine, Unity Health Toronto, Toronto, Ontario, Canada.ORCID 0009-0005-7285-3437
Ramzi Fattouh *Division of Microbiology, Department of Laboratory Medicine, Unity Health Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-6573-6367

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infection with carbapenemase-producing organisms (CPOs) is associated with significant morbidity and mortality among hospitalized patients. Thus, the identification of CPOs is an important function of clinical microbiology laboratories. This study evaluates the performance of two lateral flow assays (LFAs), the NG-Test CARBA 5 (CARBA 5) and Genobio K.N.I.V.O. Detection K-Set (Genobio), for the detection of carbapenemases using well-characterized clinical and reference isolates of gram-negative bacterial species. Both LFAs are designed to detect KPC, NDM, VIM, IMP, and OXA-48-like carbapenemases from bacterial growth within 15 minutes. In total, 152 isolates were tested: 10

Indexed as

Bacterial Proteinsbeta-LactamasesGram-Negative BacteriaAcinetobacter baumanniiEnterobacteriaceaeHumansPseudomonas aeruginosaSensitivity and SpecificityBacterial Proteinsbeta-Lactamasescarbapenemaseantibiotic resistancebacteriacarbapenemaseclinical microbiologydiagnosticsmedical microbiology

Identifiers

PMID40679301
PMCPMC12323310

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.