Evidence map›Paper›PMID 40679299›Full record

ArticleJournal of the American Chemical Society2025

Structural Basis for Oxidized Glutathione Recognition by Yeast Cadmium Factor 1.

Tik Hang Soong, Clare F Hotze, Darpan Raghav, Nitesh Kumar Khandelwal, Thomas M Tomasiak

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Tik Hang SoongDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
Clare F HotzeDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
Darpan RaghavDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
Nitesh Kumar KhandelwalDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
Thomas M TomasiakDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.ORCID 0000-0002-5884-5968

Funding

ATP Binding Cassette (ABC) Transporters in Fungal Drug ToleranceR01AI156270 · NIAID · UNIVERSITY OF ARIZONA · PI TOMASIAK, THOMAS MICHAEL · 2021 to 2025
$1.9M
NIAID NIH HHS R01 AI156270
6 · The paper itself

Abstract

Transporters from the ABCC family have an essential role in detoxifying electrophilic compounds, including heavy metals and drugs, often after conjugation with glutathione. The Yeast Cadmium Factor 1 (Ycf1) transports glutathione conjugated to toxic heavy metals including Cd

Indexed as

GlutathioneSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsBinding SitesCadmiumCryoelectron MicroscopyMolecular Dynamics SimulationOxidation-ReductionCadmiumGlutathioneSaccharomyces cerevisiae Proteins

Identifiers

PMID40679299
PMCPMC13310551

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.