ReviewApplied and environmental microbiology2025
Nucleomodulins from gut bacteria: diverse mechanisms of translocation and interaction with host nuclear processes.
Review in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Intracellular Staphylococcus aureus triggers isolate-specific host transcriptional responses alongside TNF-R1 regulated cell fate decisions.Cell communication and signaling : CCS · 2026Article
- Review
- Identification of candidate nucleomodulins in ESKAPE bacteria -Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleomodulins (NMs) are bacterial nuclear-targeted effector proteins that interfere with a multitude of host cellular processes to shield pathogens from host immune responses. Recent years observed a surge in NM-related research owing to their potential role in both infectious diseases and cancer development. However, considering the complex nature of the interaction between NM and host factors, the field of "NM-disease axis" is still in the nascent phase. Thus, a comprehensive view of the known mechanisms of translocation of NMs to the host cell nucleus and mode of action, thereafter, is crucial toward deeper exploration of the "NM-disease axis." The human gut is the major host niche to harbor bacterial cells (as part of "gut microbiota"). The current review provides an extensive collation of nucleomodulin-mediated mechanisms employed by opportunistic gut pathogens. The insights from the review would help in designing future experiments toward utilizing the NM-associated host-pathogen interaction modules in disease diagnostics and therapy.
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Registered trials
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