ArticleHuman vaccines & immunotherapeutics2025
Hyponatremia predicts immunotherapy resistance in biliary tract cancer.
Article in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- Immune checkpoint inhibitor-associated severe hyponatremia: evidence mapping of SIADH-like phenotypes and endocrine immune-related adverse events.Endocrine connections · 2026Article
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5 authors.
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Abstract
Hyponatremia, a common electrolyte imbalance in cancer patients, has frequently been disregarded in terms of its prognostic implications for immunotherapy. This study examined the prognostic implications of pre-treatment hyponatremia in patients with biliary tract cancers (BTC) undergoing immunotherapy. We retrospectively included 112 BTC patients who received immune checkpoint inhibitors (ICIs) treatment from August 2016 to December 2024, with an average follow-up period of 11.25 months. In accordance with the diagnosis of hyponatremia before the first ICIs treatment, patients were divided into two distinct groups. There were no significant differences in age (OR = 0.6, 95% CI, 0.2-1.8) or gender distribution (OR = 0.8, 95% CI, 0.3-2.4). Kaplan-Meier curves and the Mantel-Haenszel log-rank test were utilized to compare progression-free survival (PFS) and overall survival (OS) among groups. Cox and logistic regressions were employed to analyze the relationship between serum sodium levels and prognosis in 112 BTC patients, considering baseline characteristics. Patients with hyponatremia demonstrated reduced PFS (6 vs. 9 months,
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