Evidence map›Paper›PMID 40679250›Full record

ArticleEnvironmental science & technology2025

Dentin Metal and Trace Elements in Deciduous Teeth: Findings from Project Viva.

Pi-I D Lin, Christine Austin, Yi Ying Ong, Sheryl L Rifas-Shiman, Mohammad L Rahman, Manish Arora, Emily Oken

Abstract read
In one paragraph

Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Defining the developmental exposome of the neonatal intensive care unit in preterm infants.Journal of exposure science & environmental epidemiology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pi-I D LinDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215, United States.ORCID 0000-0003-3564-4255
Christine AustinDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.ORCID 0000-0002-9966-0492
Yi Ying OngDepartment of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.ORCID 0000-0003-3072-765X
Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215, United States.
Mohammad L RahmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20850, United States.
Manish AroraDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215, United States.

Funding

Untargeted Analysis ResourceU2CES026561 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROBERT O · 2015 to 2025
$24.5M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2014 to 2026
$21.3M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Untargeted Analysis ResourceU2CES030859 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARORA, MANISH · 2019 to 2025
$8.2M
Early Warning Systems for Childhood and Adult DisordersR35ES030435 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2020 to 2026
$6.7M
Organic-metal mixtures and neurodevelopmentR01ES026033 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora, Robert O Wright · 2016 to 2026
$6.1M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUG3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI KLEINMAN, KENNETH P., OKEN, EMILY · 2016 to 2017
$4.1M
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescenceR24ES030894 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2020 to 2024
$2.0M
NICHD NIH HHS R01 HD034568NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES026033NIEHS NIH HHS R24 ES030894NIEHS NIH HHS R35 ES030435NIEHS NIH HHS U2C ES026561NIEHS NIH HHS U2C ES030859NIH HHS UG3 OD023286
6 · The paper itself

Abstract

Deciduous teeth can reveal historical exposure to metals, yet their distribution within populations remains underexplored. This study aimed to characterize metal levels in deciduous teeth, compare measurements across duplicate teeth, and assess associations with maternal blood metal concentrations during pregnancy, while considering maternal and child characteristics. We recruited women into Project Viva between 1999 and 2002 during early pregnancy. During follow-up study visits between 2017 and 2020, the women provided their child's deciduous teeth. Dentin metal concentrations were analyzed using laser ablation-inductively coupled plasma-mass spectrometry, covering a measurement range from 21 weeks before to 55 weeks after birth. Multiple teeth were compared using Bland-Altman plots and cross-correlations. Maternal erythrocyte metals were measured in the first and second trimesters using ICP-MS. Significant positive correlations were found between maternal erythrocyte Pb and child's dentin Pb, particularly with the strongest association observed between second trimester maternal Pb and prenatal dentin Pb (Spearman

Indexed as

DentinMetalsTooth, DeciduousTrace ElementsAdultFemaleHumansPregnancyMetalsTrace Elementsbiomarkersdeciduous teethdentinmetalprenatal

Identifiers

PMID40679250
PMCPMC13656756

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.