SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2026
Bisphosphonate use in patients undergoing total knee arthroplasty reduces overall and aseptic revisions and periprosthetic bone mineral density loss: A systematic review from the FP-UCBM Knee Study Group.
Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bisphosphonate use in patients undergoing total knee arthroplasty reduces overall and aseptic revisions and periprosthetic bone mineral density loss: A systematic review from the FP-UCBM Knee Study Group.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Pooled it
- Antiresorptive Therapy and Revision Risk After Primary Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.Arthroplasty today · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBisphosphonates (BPs), widely used for osteoporosis management, have garnered attention in the context of total knee arthroplasty (TKA) for their potential to preserve periprosthetic bone mineral density (BMD) and mitigate risks such as aseptic loosening, periprosthetic fractures, and implant failure. This study systematically reviewed the current literature on the topic, hypothesising that BP therapy reduces the risk of postoperative adverse outcomes in patients undergoing TKA.
methodsA systematic literature search was conducted on 1 December 2024 using PubMed, Cochrane Library, Scopus and Google Scholar. Inclusion criteria were: English-language randomised controlled trials (RCTs), comparative prospective or retrospective studies, and studies evaluating postoperative outcomes (including all-cause and aseptic revisions, periprosthetic BMD loss, periprosthetic fractures and implant migration) in patients undergoing TKA who received BP treatment. Exclusion criteria were: computational studies; case reports; studies focusing uniquely on the surgical technique; studies reporting only cumulative data for total joint arthroplasty.
resultsA total of 14 studies (480,294 patients) were included. Six studies focused exclusively on osteoporotic patients, six on non-osteoporotic patients and two on a mixed BMD population. The rate of all-cause and aseptic revisions was 1.5% and 1.1% respectively for BP users, and 2.3% and 2.5%, for non-BP users. Mean pre-/post-operative variation in BMD was -0.04 for BP users and -0.2 for non-BP users. The risk of bias was graded as low using the ROB 2 tool for RCTs and the Newcastle-Ottawa Scale for observational studies.
conclusionBisphosphonate use in patients undergoing total knee arthroplasty is associated with lower rates of overall and aseptic revisions, reduced periprosthetic BMD loss, and inconclusive effects on periprosthetic fractures and implant migration. LEVEL OF EVIDENCE: Level IV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.