Trial reportThe Journal of international medical research2025
Appropriateness and safety of using the intranasal route for sedation during pediatric computed tomography: A randomized controlled trial at Korle-Bu teaching hospital.
Trial report in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Intranasal and Oral Pharmacological Sedation in Pediatric Dentistry: A Thematic Scoping Review of Efficacy, Recovery, and Safety Outcomes.Children (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveThis study aimed to determine the effectiveness and safety of using intranasal ketamine, midazolam, or their combination for sedation during pediatric computed tomography.MethodIn this randomized, double-blind study, 60 children aged ≤2.5 years who were scheduled to undergo computed tomography were allocated into the following three groups: Group K (ketamine 10 mg/kg), Group M (midazolam 0.2 mg/kg), and Group C (ketamine 7.5 mg/kg + midazolam 0.1 mg/kg). In all cases, the drugs were administered intranasally. Sedation parameters were assessed.ResultOf the 60 randomized participants, 10 were excluded due to failed sedation. Data from 16 (Group M), 14 (Group K), and 20 (Group C) participants were analyzed. The mean sedation scores were similar: Groups K (2.86 ± 0.38), M (2.63 ± 0.74), and C (2.70 ± 0.68) (p = 0.579). Time to adequate sedation was shortest in Group C (22 ± 9 min; p = 0.022). Recovery was fastest in Group M (63 ± 25 min; p = 0.007). Discharge times differed significantly (p = 0.036) among the groups, with Group M exhibiting a discharge time of 92 ± 29 min. Group C had superior parental separation scores compared with the other groups (p = 0.035).ConclusionIntranasal administration of ketamine, midazolam, or their combination is safe and effective for inducing sedation during computed tomography in pediatric patients with minimal side effects.
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