Trial reportPaediatric anaesthesia2026
Lung Volume Change Under Apnoeic Oxygenation With Different Flow Rates in Children: A Single-Centre Prospective Randomized Controlled Non-Inferiority Trial.
Trial report in Paediatric anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Efficacy of a lung recruitment manoeuvre in children undergoing general anaesthesia with a supraglottic airway.British journal of anaesthesia · 2025Trial
- [Anesthesia in neonates and preterm infants : Current knowledge on ventilation, circulation and transfusion].Die Anaesthesiologie · 2026Review
- A Novel Mixed Stimulation Pattern for Balanced Pulmonary EIT Imaging Performance.Bioengineering (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundHigh-flow oxygen in children prolongs the apnea time. The exact mechanism remains unclear.
aimsThis study investigated whether low- and high-flow nasal oxygen are non-inferior to very high-flow oxygen in preventing lung volume loss during apnoea in children under general anesthesia. We also examined whether early onset oxygen using the Optiflow Switch cannula reduces lung volume loss compared to conventional late-onset application. Finally, we assessed the timing and regional distribution of lung volume changes using electrical impedance tomography (EIT).
methodsWe conducted a single center randomized controlled non-inferiority trial. After Ethics Committee approval and informed consent, we recruited 108 children (ASA1 and 2, 10-20 kg) undergoing elective general anesthesia. The primary endpoint was the normalized reduction in lung volume in relation to body weight (mL kg
results89/108 children were analyzed (low-flow n = 20, high-flow n = 24, very high-flow n = 21 and early onset high-flow n = 24.). The estimated mean (95% CI) reduction in lung volume was: low-flow 5.9 (5.3-7.8) mL kg
conclusionsApnoeic oxygenation with low-flow is non-inferior to very high-flow regarding lung volume loss in children. An early onset of apnoeic oxygenation after facemask ventilation may delay lung volume loss during apnoea.
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Registered trials
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