Evidence map›Paper›PMID 40679114›Full record

ReviewInternational forum of allergy & rhinology2025

Enhancing Diagnostic Accuracy in Sinonasal Neuroendocrine Tumors: The Case for DOTATATE PET Over FDG PET.

Michael Sabbaj, Anandraj Kanwar, Jessica W Grayson, Nyall R London, Shirley Y Su, Carl H Snyderman, Brian D Thorp, Dennis Tang, David Gudis, Eric W Wang and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International forum of allergy & rhinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michael SabbajUniversity of Vermont Larner College of Medicine, Burlington, Vermont, USA.ORCID 0000-0002-1069-7855
Anandraj KanwarDepartment of Radiology, New Orleans University Medical Center Hospital, New Orleans, Louisiana, USA.
Jessica W GraysonDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama, Birmingham, Alabama, USA.ORCID 0000-0002-2131-8005
Nyall R LondonDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Shirley Y SuDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Carl H SnydermanDepartment of Otolaryngology, Center for Skull Base Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-8920-4522
Brian D ThorpDepartment of Otolaryngology, Center for Skull Base Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
Dennis TangDepartment of Otolaryngology-Head and Neck Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
David GudisDepartment of Otolaryngology-Head and Neck Surgery, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-1938-9349
Eric W WangDepartment of Otolaryngology, Center for Skull Base Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-1180-5854
Edward C KuanDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange, California, USA.
Garett W ChobyDepartment of Otolaryngology, Center for Skull Base Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-3745-2727
Mathew GeltzeilerDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroendocrine tumors (NET) are a heterogeneous group of neoplasms that arise from neuroendocrine cells and commonly originate in the GI tract, lungs, and pancreas, but can also present in the skull base and paranasal sinuses. While fluorodeoxyglucose positron emission tomography (FDG PET) scans are routinely used in the evaluation of sinonasal malignancies, their limitations in detecting recurrences near the cranium and cervical lymph node metastases in NETs such as olfactory neuroblastoma (ONB) and sinonasal neuroendocrine carcinomas (SNEC) have prompted the search for an alternative imaging modality. Somatostatin receptor 2 (SSTR2) is a membrane-bound G protein expressed in several types of neuroendocrine and neural cells. Notably, it is also expressed almost ubiquitously in ONB and SNEC. Gallium-68 DOTATATE PET scans (68Ga-DOTATATE) utilize a somatostatin analog as a targeting imaging modality. The efficacy of 68Ga-DOTATATE scan has been well established for gastrointestinal NETs, but its place in head and neck cancers is still under investigation. Importantly, SSTR2 expression also opens avenues for peptide receptor radionuclide therapy (PRRT), further broadening its clinical utility. Given the limitations of FDG PET scans, 68Ga-DOTATATE PET scans should be incorporated into routine practice when staging and monitoring for recurrences in ONB and SNEC.

Indexed as

Fluorodeoxyglucose F18Neuroendocrine TumorsNose NeoplasmsOrganometallic CompoundsParanasal Sinus NeoplasmsPositron-Emission TomographyEsthesioneuroblastoma, OlfactoryHumansRadiopharmaceuticalsReceptors, SomatostatinFluorodeoxyglucose F18gallium Ga 68 dotatateOrganometallic CompoundsRadiopharmaceuticalsReceptors, SomatostatinDotatateesthesioneuroblastomaneuroendocrine carcinomaoctreotideolfactory neuroblastomapositron‐emission tomographysomatostatin

Identifiers

PMID40679114
PMCPMC12503079

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.