Evidence map›Paper›PMID 40679079›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

METTL3/ALKBH5-Mediated N6-Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3-TASL-IRF5 Signaling Axis in Psoriasis.

Tao Huang, Shijun Chen, Ke Ding, Liyan Yuan, Weiqi Lv, Kechen Chen, Yuchen Liu, Dongzhao Ma, Xin Zhang, Xiaobo Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. RNA mActa pharmacologica Sinica · 2026
    Review
  3. METTL7A-Dependent mMedComm · 2026
    Article
  4. The Role of NMedComm · 2026
    Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tao HuangDermatology Hospital, Southern Medical University, Guangzhou, 510091, China.ORCID https://orcid.org/0000-0002-6701-6555
Shijun ChenCancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, Southern Medical University, Guangzhou, 510515, China.ORCID https://orcid.org/0000-0002-2879-4178
Ke DingDermatology Hospital, Southern Medical University, Guangzhou, 510091, China.ORCID https://orcid.org/0000-0002-1560-0549
Liyan YuanDermatology Hospital, Southern Medical University, Guangzhou, 510091, China.ORCID https://orcid.org/0009-0009-4201-1705
Weiqi LvDermatology Hospital, Southern Medical University, Guangzhou, 510091, China.ORCID https://orcid.org/0000-0002-5872-3151
Kechen ChenCancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, Southern Medical University, Guangzhou, 510515, China.ORCID https://orcid.org/0009-0006-4697-0696
Yuchen LiuCancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, Southern Medical University, Guangzhou, 510515, China.ORCID https://orcid.org/0000-0002-9195-9465
Dongzhao MaMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510275, China.ORCID https://orcid.org/0000-0002-4606-4339
Xin ZhangCancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, Southern Medical University, Guangzhou, 510515, China.ORCID https://orcid.org/0000-0002-1338-5320
Xiaobo WangCancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, Southern Medical University, Guangzhou, 510515, China.ORCID https://orcid.org/0000-0003-3165-5109
Guanzheng LuoMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510275, China.ORCID https://orcid.org/0000-0002-6797-9319
Bin YangDermatology Hospital, Southern Medical University, Guangzhou, 510091, China.ORCID https://orcid.org/0000-0002-7155-6079
Ying LinCancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, Southern Medical University, Guangzhou, 510515, China.ORCID https://orcid.org/0000-0002-3876-5653
Zhili RongDermatology Hospital, Southern Medical University, Guangzhou, 510091, China.ORCID https://orcid.org/0000-0002-1699-7074

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515012269Basic and Applied Basic Research Foundation of Guangdong Province 2023B1111050005Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515012753Basic and Applied Basic Research Foundation of Guangdong Province 2025A1515012794Guangzhou Basic and Applied Basic Research Foundation 2025A04J4034Major Project of Guangzhou National Laboratory GZNL2023A03004National Key R&D Program of China 2022YFA0806303National Natural Science Foundation of China 82304008National Natural Science Foundation of China 82370003National Natural Science Foundation of China 82370078
6 · The paper itself

Abstract

Impaired N6-methyladenosine (m

Indexed as

AdenosineAlkB Homolog 5, RNA DemethylaseInterferon Regulatory FactorsMacrophagesMethyltransferasesPsoriasisAnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, KnockoutSignal TransductionAdenosineAlkB Homolog 5, RNA DemethylaseInterferon Regulatory FactorsIrf5 protein, mouseMethyltransferasesMettl3 protein, mouseN-methyladenosinemacrophage polarizationN6‐methyladenosinepsoriasisSLC15A3TASL

Identifiers

PMID40679079
PMCPMC12462922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.