Evidence map›Paper›PMID 40679061›Full record

ReviewLiver international : official journal of the International Association for the Study of the Liver2025

Liver Involvement in Celiac Disease and Immune-Mediated Diseases of the Small Bowel.

Nicoletta Nandi, Elena F Verdu, Detlef Schuppan, Andres Jose Gomez-Aldana, Maria Ines Pinto-Sanchez, Francesco Simone Conforti, Marco Maggioni, Flavio Caprioli, Luca Elli

Abstract readReview
In one paragraph

Review in Liver international : official journal of the International Association for the Study of the Liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Liver Involvement in Celiac Disease and Immune-Mediated Diseases of the Small Bowel.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nicoletta NandiGastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.ORCID 0000-0002-4450-2593
Elena F VerduDepartment of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-6346-2665
Detlef SchuppanInstitute of Translational Immunology and Research Center for Immune Therapy, University Medical Center, Mainz, Germany.ORCID 0000-0002-4972-1293
Andres Jose Gomez-AldanaDivision of Digestive Diseases, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0002-7954-4910
Maria Ines Pinto-SanchezDepartment of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-9040-9824
Francesco Simone ConfortiGastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Marco MaggioniDivision of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Flavio CaprioliGastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.ORCID 0000-0002-8077-8175
Luca ElliGastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.ORCID 0000-0002-0873-0759

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disorders of the hepatobiliary system are commonly associated with gastrointestinal (GI) diseases. The GI and hepatobiliary systems interact through the portal vein system and enterohepatic circulation, creating a gut-liver axis that allows for a complex multidirectional interplay between immune, hormonal, dietary and environmental luminal factors that include the gut microbiota. This interaction may underlie the liver affection in autoimmune and immune-mediated small bowel diseases through a variety of pathways that include autoimmune, metabolic, immune-mediated, and/or iatrogenic mechanisms. Despite evidence of a gut-liver axis and co-morbid liver associations with small bowel diseases, the clinical implications and how these conditions should be clinically managed remain unclear. In this narrative review, we describe the hepato-biliary manifestations associated with chronic immune-mediated enteropathies of the small bowel in adults, with particular focus on CeD and Crohn's disease.

Indexed as

Celiac DiseaseCrohn DiseaseLiverLiver DiseasesGastrointestinal MicrobiomeHumansIntestine, Smallautoimmune hepatitisceliac diseaseCrohn's diseasesmall bowel

Identifiers

PMID40679061
PMCPMC12272813

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.