Evidence map›Paper›PMID 40679030›Full record

ArticleAdvanced biology2025

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis.

Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic

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PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Diana CoralloLaboratory of Target Discovery and Biology of Neuroblastoma, Pediatric Hematology, Oncology and Hematopoietic Cell&Gene Therapy Research Area, Institute of Pediatric Research, Fondazione Città della Speranza, Padua, 35127, Italy.ORCID https://orcid.org/0000-0001-7075-1414
Sara MenegazzoLaboratory of Target Discovery and Biology of Neuroblastoma, Pediatric Hematology, Oncology and Hematopoietic Cell&Gene Therapy Research Area, Institute of Pediatric Research, Fondazione Città della Speranza, Padua, 35127, Italy.ORCID https://orcid.org/0000-0002-3886-4360
Marcella PantileLaboratory of Target Discovery and Biology of Neuroblastoma, Pediatric Hematology, Oncology and Hematopoietic Cell&Gene Therapy Research Area, Institute of Pediatric Research, Fondazione Città della Speranza, Padua, 35127, Italy.
Silvia BresolinInstitute of Pediatric Research, Fondazione Città della Speranza, Padua, 35127, Italy.
Carlo ZanonInstitute of Pediatric Research, Fondazione Città della Speranza, Padua, 35127, Italy.
Alessandro DaviniLaboratory of Target Discovery and Biology of Neuroblastoma, Pediatric Hematology, Oncology and Hematopoietic Cell&Gene Therapy Research Area, Institute of Pediatric Research, Fondazione Città della Speranza, Padua, 35127, Italy.
Massimiliano MazzoneLaboratory of Tumor Inflammation and Angiogenesis, VIB KU Leuven Center for Cancer Biology, Leuven, 3000, Belgium.
Alessandra BiffiDivision of Pediatric Hematology, Oncology, and Stem Cell Transplant, Department of Woman's and Child's Health, University of Padua, Padua, 35128, Italy.
Sanja AveicLaboratory of Target Discovery and Biology of Neuroblastoma, Pediatric Hematology, Oncology and Hematopoietic Cell&Gene Therapy Research Area, Institute of Pediatric Research, Fondazione Città della Speranza, Padua, 35127, Italy.

Funding

Associazione Italiana per la Lotta al NeuroblastomaFondazione AIRC per la ricerca sul cancro ETS 26484Fondazione Cassa di Risparmio di Padova e Rovigo 20/11Fondazione Umberto Veronesi 5260
6 · The paper itself

Abstract

Neuroblastoma represents a major challenge in pediatric oncology with over 50% of cases involving metastasis. High-risk patients face an unfavorable prognosis, with survival rates below 40%. LIN28B plays a pivotal role in neuroblastoma development, being overexpressed in a subset of high-risk patients with widespread metastases. Here, the effect of induced LIN28B (iLIN28B) expression on neuroblastoma cells is investigated with a focus on key aspects of the metastatic cascade including anchorage, migration, invasion, and angiogenesis. iLIN28B cells show substrate-selective adherence, coating-dependent migration, and the context-guided ability to degrade the extracellular matrix. In response to tumor cell-derived IGF2, endothelial cells show enhanced motility and proliferation, while inhibition of IGF2 activity impairs LIN28B-induced angiogenesis in vitro and in vivo. These findings underscore the hub role of LIN28B in favoring pre-metastatic processes in neuroblastoma. The intricate interplay between LIN28B, endothelial cells, and the extracellular matrix contributes to the development of the aggressive neuroblastoma phenotypes.

Indexed as

Neovascularization, PathologicNeuroblastomaRNA-Binding ProteinsAngiogenesisAnimalsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansMiceLIN28B protein, humanRNA-Binding ProteinsangiogenesisLIN28Bmigrationneuroblastomapre‐metastatic niche

Identifiers

PMID40679030
PMCPMC12624821

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.