Evidence map›Paper›PMID 40678973›Full record

ArticleCancer reports (Hoboken, N.J.)2025

Clinical Relationship Between Serum ApoB, HER2, and Myocardial Ischemia Risk in Breast Cancer Patients.

Yeyan Lei, Dongmei Li, Shuang Bai, Xing Zeng, Rongyuan Yang, Qing Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yeyan LeiZhuhai Doumen Maternal and Child Health Care Hospital, Guangdong Provincial Hospital of Chinese Medicine-Zhuhai Hospital, the Second Clinical School of Medicine, Guangzhou University of Chinese Medicine, Zhuhai, China.
Dongmei LiZhuhai Doumen Maternal and Child Health Care Hospital, Guangdong Provincial Hospital of Chinese Medicine-Zhuhai Hospital, the Second Clinical School of Medicine, Guangzhou University of Chinese Medicine, Zhuhai, China.
Shuang BaiZhuhai Doumen Maternal and Child Health Care Hospital, Guangdong Provincial Hospital of Chinese Medicine-Zhuhai Hospital, the Second Clinical School of Medicine, Guangzhou University of Chinese Medicine, Zhuhai, China.
Xing ZengDepartment of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, China.
Rongyuan YangZhuhai Doumen Maternal and Child Health Care Hospital, Guangdong Provincial Hospital of Chinese Medicine-Zhuhai Hospital, the Second Clinical School of Medicine, Guangzhou University of Chinese Medicine, Zhuhai, China.
Qing LiuZhuhai Doumen Maternal and Child Health Care Hospital, Guangdong Provincial Hospital of Chinese Medicine-Zhuhai Hospital, the Second Clinical School of Medicine, Guangzhou University of Chinese Medicine, Zhuhai, China.ORCID 0000-0002-2199-2999

Funding

Guangzhou Municipal Science and Technology BureauNational Natural Science Foundation of China
6 · The paper itself

Abstract

backgroundThe risk factors and clinical prediction of cardiovascular comorbidities in patients with breast cancer have not been fully clarified.

aimsThis retrospective case-control study was designed to investigate the factors affecting myocardial ischemia occurrence in breast cancer patients. METHODS AND

resultsA total of 194 cases (144 breast cancer and 50 benign breast tumor patients) were included. Univariate and multivariable Cox regression found that ApoB, age, and HER2 were significant factors responsible for the myocardial ischemia occurrence in breast cancer patients. By comparing the significance of ApoB in breast cancer patients versus benign breast tumor patients, it was observed that ApoB and HER2 were crucial predictors of myocardial ischemia in breast cancer patients compared to those with benign breast tumors. These factors were utilized to construct the clinical prediction model, achieving a combined area under the curve (AUC) of 0.583. The decision curve analysis (DCA) indicated that the model-predicted population, within a threshold ranging from 0.35 to 0.70, would experience a therapeutically clinical net benefit. Kaplan-Meier plot indicated that ApoB

conclusionWe demonstrated that ApoB and HER2 were potential factors in predicting the myocardial ischemia occurrence in breast cancer patients. This study will help provide clinical evidence for the early prediction of cardiovascular comorbidities in breast cancer patients.

Indexed as

Apolipoprotein B-100Breast NeoplasmsErb-b2 Receptor Tyrosine KinasesMyocardial IschemiaAdultAgedCase-Control StudiesFemaleFollow-Up StudiesHumansMiddle AgedPrognosisRetrospective StudiesRisk AssessmentRisk FactorsAPOB protein, humanApolipoprotein B-100ERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesApoB and HER2breast cancercase–control studyclinical prediction modelmyocardial ischemia risk

Identifiers

PMID40678973
PMCPMC12272302

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.