Evidence map›Paper›PMID 40678939›Full record

ReviewFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

NKp30: A Key Membrane Molecule in the Fight Against Cancer and Infection.

Yushu Shao, Yang Zhang, Jiaying Cao, Junyu He, Qian He, Yan Lei, Ning Tang, Yanhong Zhou

Abstract readReview
In one paragraph

Review in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. NKp30: A Key Membrane Molecule in the Fight Against Cancer and Infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yushu ShaoDepartment of Blood Transfusion, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, China.
Yang ZhangCancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan, China.
Jiaying CaoCancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan, China.
Junyu HeCancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan, China.
Qian HeDepartment of Radiation Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, China.
Yan LeiDepartment of Blood Transfusion, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, China.
Ning TangOffice of Scientific Research Administration, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, China.
Yanhong ZhouCancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0000-0002-9498-4439

Funding

Health Commission of Hunan Province () D202307016531HSTD | Natural Science Foundation of Hunan Province () 2022JJ30328HSTD | Natural Science Foundation of Hunan Province () 2025JJ50488HSTD | Natural Science Foundation of Hunan Province () 2025JJ80826
6 · The paper itself

Abstract

Natural killer cells (NK) are crucial components of the immune system. NKp30, a significant activation receptor on the NK cell membrane, plays a cytotoxic role by recognizing and binding to corresponding ligands. This interaction mediates the activation of NK cells and the release of regulatory factors, participating in antitumor and anti-infection processes. This review systematically summarizes the structural features and basic functions of NKp30, the impact of N-terminal glycosylation on NKp30 function, related NKp30 ligands and their roles, as well as the antitumor and anti-infective functions and mechanisms of NKp30. The aim is to provide a new perspective for a comprehensive understanding of NKp30 function.

Indexed as

InfectionsKiller Cells, NaturalNatural Cytotoxicity Triggering Receptor 3NeoplasmsAnimalsHumansNatural Cytotoxicity Triggering Receptor 3NCR3 protein, humananti‐infectionantitumormechanismsnatural killer cellNKp30

Identifiers

PMID40678939
PMCPMC12272517

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.