ArticleJournal of veterinary internal medicine
Longitudinal Assessment and Cost-Benefit Analysis of Prophylactic Fenestration in Chondrodystrophic Dogs With Follow-Up Magnetic Resonance Imaging.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Computed tomography versus magnetic resonance imaging for the perioperative management of acute thoracolumbar intervertebral disc extrusion in non-ambulatory chondrodystrophic dogs.Veterinary surgery : VS · 2026Article
- Comparative cost-effectiveness of cross-sectional imaging strategies in the diagnosis of intervertebral disc extrusion in dogs: a United Kingdom-based decision-analytic study.Journal of veterinary internal medicine · 2026Article
- Longitudinal Assessment and Cost-Benefit Analysis of Prophylactic Fenestration in Chondrodystrophic Dogs With Follow-Up Magnetic Resonance Imaging.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProphylactic fenestration (PF) has been reported to protect against recurrent intervertebral disc extrusion (IVDE), but recurrence is not always confirmed. No published studies address the cost-benefit of PF.
objectivesObserve the association between PF and intervertebral disc (IVD) survival and conduct cost-benefit analysis. ANIMALS: Eighty chondrodystrophic dogs with recurrent IVDE.
methodsLongitudinal assessment with follow-up magnetic resonance imaging (MRI) was performed to retrospectively observe the survival of in situ IVDs. The association between PF and IVD survival was analyzed using a multivariable survival model, which included Pfirrmann grade as a covariate. Worst-case, base-case, and best-case cost-benefit simulations were conducted, corresponding to the lower 95% confidence interval (CI), point estimate, and upper 95% CI of the effect size of PF.
resultsFor IVDs treated with PF, 4/31 (12.9%) IVDs were documented to subsequently extrude on follow-up MRI. For IVDs not treated with PF, 76/602 (12.6%) were documented to subsequently extrude on follow-up MRI. There was no association between the use of PF and IVD survival (time ratio: 1.17; 95% CI: 0.49-2.76; p = 0.72). An increase in Pfirrmann grade was associated with a decrease in IVD survival (time ratio: 0.34; 95% CI: 0.26-0.46; p < 0.001). Prophylactic fenestration was only cost-effective under a limited range of conditions. CONCLUSIONS AND CLINICAL IMPORTANCE: There was no evidence that PF prevented IVDE under study conditions. Pfirrmann grade was the strongest predictor of IVD survival. Universal use of PF was not cost-effective in multiple simulations. Targeted PF of high-risk IVDs may be considered the most cost-effective approach.
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