ArticleBiochemistry and biophysics reports2025
Genetic architecture and mechanisms shared between kidney and ureteral stones, cardiovascular diseases, and metabolic syndrome: A comprehensive GWAS analysis.
Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Causal association between sleep disorders and nephrolithiasis: a two-sample Mendelian randomization study.International urology and nephrology · 2026Article
- Cardiovascular-kidney-metabolic syndrome: a comprehensive review of pathophysiology, epidemiology, diagnosis, and management.Cardiovascular diabetology · 2026Review
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Authors and funding
5 authors.
Funding
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Abstract
Background: Our study aims to investigate the shared genetic architecture between kidney and ureteral stones (KUS) and cardiovascular diseases (CVDs), as well as metabolic syndrome (MetS), and explore the shared risk loci, potentially critical tissues and relevant genetic mechanisms. Methods: Dependent on large-scale genome-wide association study (GWAS) summary-level data sets, we observed genetic correlations between KUS and CVDs, as well as MetS, and cross-diseases pleiotropic analysis was conducted to identify shared pleiotropic loci and genes. Furthermore, we performed functional annotation and tissue-specific analysis to detect potential relationships between complex traits. We performed heritability enrichment analysis to determine potentially critical tissues. At last, we investigate the causal effects between KUS and other traits using bidirectional Mendelian randomization (MR). Results: Our findings underlined shared genetic architecture between three CVDs, two MetS and KUS. We identified 937 pleiotropic loci at the genome-wide significance level (p < 5 × 10 Conclusions: Our study determined shared genetic architecture between KUS and CVDs, as well as MetS, and unraveled underlying genetic mechanisms.
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