Evidence map›Paper›PMID 40678754›Full record

ArticleFrontiers in neuroscience2025

Alpha-synuclein null mutation exacerbates the phenotype of a model of Menkes disease in female mice.

MegAnne Casey, Dan Zou, Renee A Reijo Pera, Tiffany Hensley-McBain, Deborah E Cabin

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

MegAnne CaseyMcLaughlin Research Institute, Weissman Hood Institute at Touro University, Great Falls, MT, United States.
Dan ZouMcLaughlin Research Institute, Weissman Hood Institute at Touro University, Great Falls, MT, United States.
Renee A Reijo PeraMcLaughlin Research Institute, Weissman Hood Institute at Touro University, Great Falls, MT, United States.
Tiffany Hensley-McBainMcLaughlin Research Institute, Weissman Hood Institute at Touro University, Great Falls, MT, United States.
Deborah E CabinMcLaughlin Research Institute, Weissman Hood Institute at Touro University, Great Falls, MT, United States.

Funding

Modulation of Exosome Release for Functional Restoration in Age-related Retinal DisordersP20GM152335 · NIGMS · MC LAUGHLIN RESEARCH INSTITUTE · PI Brenda F Canine · 2024 to 2026
$11.1M
Mutant human a-synuclein toxicity in miceR01NS062121 · NINDS · MC LAUGHLIN RESEARCH INSTITUTE · PI CABIN, DEBORAH E · 2008 to 2012
$1.6M
NIGMS NIH HHS P20 GM152335NINDS NIH HHS R01 NS062121
6 · The paper itself

Abstract

Human

Indexed as

Atp7aENU mutagenesisMenkes diseaseneurodegenerationParkinson’s disease

Identifiers

PMID40678754
PMCPMC12267275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.