ArticleTransboundary and emerging diseases2025
Comparative Pathogenicity of PCV2, PCV3, and PCV4 in Piglets: Insights Into Clinical, Pathological, and Immunological Features.
Article in Transboundary and emerging diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Construction andMicrobiology spectrum · 2026Article
- Epidemiological Survey of Porcine Circovirus Types 2 and 3 in Liaoning Region of China and Preparation of Monoclonal Antibodies Against PCV3 Cap Protein.Veterinary sciences · 2026Article
- Preparation and immunological effects of a bivalent subunit candidate vaccine based on the PCV-Cap-2-3 gene engineered from baculovirus.Frontiers in veterinary science · 2026Article
- Emerging Challenges and Advances in Porcine Circovirus: A Decade in Review.Transboundary and emerging diseases · 2026Review
- A porcine circovirus type 2d-based virus-like particle subunit vaccine effectively protects pigs against homologous challenge.Frontiers in microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine circoviruses (PCVs) have been a significant concern in swine health, with PCV2 being a well-established pathogen. However, the newly discovered PCV3 and PCV4 have emerged, and their impact on piglets remains less understood. Understanding their pathogenicity is crucial for effective porcine health management. In this study, 3-week-old piglets were inoculated with PCV2, PCV3, and PCV4. PCV2 led to expected growth inhibition and severe clinical signs like anorexia. PCV3, though showing milder symptoms, exhibited unique tissue tropism, with detectable virus in the heart, lungs, and brain tissues. PCV4 caused distinct tissue damage, including cardiac fibrosis and renal changes. In terms of immune responses, each virus triggered different cytokine profiles. PCV3 and PCV4 also demonstrated replication capabilities in vitro and in vivo. PCV3 and PCV4 clearly have pathogenic patterns that differ from those of PCV2. These findings provide essential insights for veterinarians and swine producers. Understanding these viruses' behavior aids in developing targeted prevention and control strategies, such as improved diagnostic tools and potential new vaccines, to enhance porcine health management and safeguard the swine industry from the threats posed by these emerging PCVs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.